Abstract
Mass spectrometry-based metabolomics provides a new approach to interrogate mechanistic biochemistry related to natural processes such as health and disease. Physiological and pathological conditions, however, are characterized not only by the identities and concentrations of metabolites present, but also by the location of metabolites within a tissue. Unfortunately, most relevant MS platforms in metabolomics can only measure samples in solution, therefore metabolites are typically extracted by tissue homogenization. Recent developments of imaging-MS technologies, however, have allowed particular metabolites to be spatially localized within biological tissues. In this context, Nanostructure-Initiator Mass Spectrometry (NIMS), a matrix-free technique for surface-based analysis, has proven an alternative approach for tissue imaging of metabolites. Here we review the basic principles of NIMS for tissue imaging and show applications that can complement LC/MS and GC/MS-based metabolomic studies investigating the mechanisms of fundamental biological processes. In addition, the new surface modifications and nanostructured materials herein presented demonstrate the versatility of NIMS surface to expand the range of detectable metabolites.
References
Mar 7, 2001·Human Molecular Genetics·C A WassifF D Porter
Mar 30, 2001·The Journal of Biological Chemistry·S J KridelJ W Smith
Feb 20, 2003·The Journal of Biological Chemistry·Emily I ChenJeffrey W Smith
Apr 29, 2004·Journal of Proteome Research·Pierre ChaurandRichard M Caprioli
Aug 16, 2005·Analytical Chemistry·Shoji OkunoYoshinao Wada
Mar 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Trent R NorthenGary Siuzdak
May 14, 2008·Analytical Chemistry·Peter NemesAkos Vertes
Aug 21, 2008·Nature Protocols·Hin-Koon WooGary Siuzdak
Mar 18, 2009·Analytical Chemistry·Sangwon ChaEdward S Yeung
Mar 24, 2009·Analytical Chemistry·Oscar YanesGary Siuzdak
May 6, 2009·Proteomics·Başak Kükrer KaletaşRon M A Heeren
May 20, 2009·Molecular & Cellular Proteomics : MCP·Julien FranckMichel Salzet
Sep 8, 2009·The Plant Journal : for Cell and Molecular Biology·Dirk HölscherAles Svatos
Dec 8, 2009·Analytical Chemistry·Gary J PattiGary Siuzdak
Jan 7, 2010·Analytical Chemistry·Peter NemesAkos Vertes
Mar 5, 2010·Diabetes·Sebastián MasJesús Egido
Jun 29, 2010·Trends in Biotechnology·Ales Svatos
Jul 31, 2010·Neuroscience·G J PattiG Siuzdak
Sep 15, 2010·Advanced Materials·Xiujuan YangR H Lipson
Nov 3, 2010·Current Opinion in Hematology·Ulf Meyer-Hoffert, Oliver Wiedow
Dec 15, 2010·Analytical Chemistry·Marion GirodR Graham Cooks
Mar 30, 2011·PloS One·Yuki SugiuraMitsutoshi Setou
Apr 26, 2011·Journal of Proteomics·Tyler GreerLingjun Li
Jun 15, 2011·Biochimica Et Biophysica Acta·Melissa K Passarelli, Nicholas Winograd
Dec 7, 2011·Analytical Chemistry·Robert F MengerRichard A Yost
Dec 14, 2011·Analytical and Bioanalytical Chemistry·Masanori YamadaSeiji Ito
Dec 28, 2011·Analytical and Bioanalytical Chemistry·Noriyuki AkahoshiIsao Ishii
Feb 23, 2012·Scientific Reports·Valentina MarchettiMartin Friedlander
Citations
Feb 23, 2013·The Analyst·Rachel MasyukoPaul W Bohn
Apr 2, 2013·Analytical Methods : Advancing Methods and Applications·Robert M SturmLingjun Li
Oct 18, 2013·The Analyst·Yuliya E Silina, Dietrich A Volmer
Mar 19, 2015·Marine Drugs·David RuddNicolas H Voelcker
Jan 8, 2016·Analytical Chemistry·Jian GaoTrent R Northen
May 15, 2015·Scientific Reports·Rong-Cing HuangChih-Ching Huang
Sep 4, 2012·Revista de gastroenterología de México·M P Milke-García
Apr 12, 2014·BioMed Research International·Gigin Lin, Yuen-Li Chung
Sep 27, 2012·Analytical Chemistry·Maurizio RonciNicolas H Voelcker
Oct 13, 2016·Proteomics. Clinical Applications·Matthew B O'Rourke, Matthew P Padula
Mar 18, 2017·Critical Reviews in Analytical Chemistry·Hubert BylińskiJacek Namieśnik
May 19, 2017·Analytical Chemistry·Jian GaoTrent R Northen
Oct 20, 2018·The Analyst·Lei YinJingkai Gu
Jan 18, 2020·Rapid Communications in Mass Spectrometry : RCM·Keiko KuwataYasuhide Naito
Nov 20, 2016·Mass Spectrometry Reviews·Pere RàfolsXavier Correig
Nov 12, 2020·Mass Spectrometry Reviews·Wendy H MüllerGauthier Eppe
Feb 18, 2021·Talanta·Xinrong JiangJianmin Wu
Jul 5, 2021·Progress in Lipid Research·Wendy H MüllerGauthier Eppe
Feb 18, 2021·Journal of the American Society for Mass Spectrometry·Amelia Palermo