Nanostructure Initiator Mass Spectrometry for tissue imaging in metabolomics: future prospects and perspectives

Journal of Proteomics
Raul CalaviaOscar Yanes

Abstract

Mass spectrometry-based metabolomics provides a new approach to interrogate mechanistic biochemistry related to natural processes such as health and disease. Physiological and pathological conditions, however, are characterized not only by the identities and concentrations of metabolites present, but also by the location of metabolites within a tissue. Unfortunately, most relevant MS platforms in metabolomics can only measure samples in solution, therefore metabolites are typically extracted by tissue homogenization. Recent developments of imaging-MS technologies, however, have allowed particular metabolites to be spatially localized within biological tissues. In this context, Nanostructure-Initiator Mass Spectrometry (NIMS), a matrix-free technique for surface-based analysis, has proven an alternative approach for tissue imaging of metabolites. Here we review the basic principles of NIMS for tissue imaging and show applications that can complement LC/MS and GC/MS-based metabolomic studies investigating the mechanisms of fundamental biological processes. In addition, the new surface modifications and nanostructured materials herein presented demonstrate the versatility of NIMS surface to expand the range of detectable metabolites.

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Citations

Feb 23, 2013·The Analyst·Rachel MasyukoPaul W Bohn
Apr 2, 2013·Analytical Methods : Advancing Methods and Applications·Robert M SturmLingjun Li
Jan 8, 2016·Analytical Chemistry·Jian GaoTrent R Northen
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Oct 20, 2018·The Analyst·Lei YinJingkai Gu
Jan 18, 2020·Rapid Communications in Mass Spectrometry : RCM·Keiko KuwataYasuhide Naito
Nov 12, 2020·Mass Spectrometry Reviews·Wendy H MüllerGauthier Eppe

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