Nanostructured Ag+ -substituted fluorhydroxyapatite-TiO2 coatings for enhanced bactericidal effects and osteoinductivity of Ti for biomedical applications

International Journal of Nanomedicine
Yong HuangXiaojun Zhang

Abstract

Poor mechanical properties, undesirable fast dissolution rate, and lack of antibacterial activity limit the application of hydroxyapatite (HA) as an implant coating material. To overcome these limitations, a hybrid coating of Ag+-substituted fluorhydroxyapatite and titania nanotube (TNT) was prepared. The incorporation of silver into the HA-TiO2 hybrid coating improves its antimicrobial properties. The addition of F as a second binary element increases the structural stability of the coating. The TNT/F-and-Ag-substituted HA (FAgHA) bilayer coating on the Ti substrate was confirmed by X-ray diffraction, scanning electron microscope, energy-dispersive X-ray spectroscopy (EDS), and X-ray photoelectron spectroscopy (XPS). The results indicate that the FAgHA/TNT nanocomposite coating has a dense and uniform morphology with a nano-rod-like structure. The solubility measurement result shows that the substitution of F- ions into the AgHA structure has a positive effect on the dissolution resistance of HA. The adhesion strength of FAgHA/TNT has significantly increased because of the interlocking of the roughened surface with nano-rod-like particles that entered into the voids of the TiO2 nanotubes. Compared with that of the bare Ti, the...Continue Reading

Citations

Mar 15, 2019·Journal of Oral Rehabilitation·Yanjing LiYunfeng Lin
Feb 9, 2020·International Journal of Environmental Research and Public Health·Simone LeonettiBeatrice Casini
Feb 18, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Daniel Arcos, María Vallet-Regí
Oct 30, 2020·International Journal of Nanomedicine·Chih-Chien HuSteve Wen-Neng Ueng

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BETA
X-ray
infrared spectroscopy
ELISA
fluorescence microscopy

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ZsimpWin

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