Nanostructured fibrin agarose hydrogel as a novel haemostatic agent

Journal of Tissue Engineering and Regenerative Medicine
Rafael Campos-CuervaMiguel Ángel Gómez-Bravo

Abstract

Blood loss remains a major concern during surgery and can increase the morbidity of the intervention. The use of topical haemostatic agents to overcome this issue therefore becomes necessary. Fibrin sealants are promising haemostatic agents due to their capacity to promote coagulation, but their effectiveness and applicability need to be improved. We have compared the haemostatic efficacy of a novel nanostructured fibrin-agarose hydrogel patch, with (c-NFAH) or without cells (a-NFAH), against two commercially available haemostatic agents in a rat model of hepatic resection. Hepatic resections were performed by making short or long incisions (mild or severe model, respectively), and haemostatic agents were applied to evaluate time to haemostasis, presence of haematoma, post-operative adhesions to adjacent tissues, and inflammation factors. We found a significantly higher haemostatic success rate (time to haemostasis) with a-NFAH than with other commercial haemostatic agents. Furthermore, other relevant outcomes investigated were also improved in the a-NFAH group, including no presence of haematoma, lower adhesions, and lower grades of haemorrhage, inflammation, and necrosis in histological analysis. Overall, these findings ident...Continue Reading

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Citations

Apr 10, 2019·Tissue Engineering. Part a·Ana B García DelgadoFrancisco J Díaz Corrales

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Methods Mentioned

BETA
biopsies
Electrophoresis
ELISA

Clinical Trials Mentioned

NCT01765244

Software Mentioned

Evarrest
Tachosil
Ikaros Karyotyping System ( Metasystems
GraphPad
GraphPad Prism

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