Nanostructured lipid carriers for parenteral delivery of silybin: Biodistribution and pharmacokinetic studies

Colloids and Surfaces. B, Biointerfaces
Lejiao JiaQiang Zhang

Abstract

The objective of the present study was to explore the potential of nanostructured lipid carriers (NLCs) for the intravenous delivery of silybin, a poorly water-soluble antihepatopathy agent. Silybin-NLC was prepared by the method of emulsion evaporation at a high temperature and solidification at a low temperature. The resultant NLC had a mean size 232.1 nm and a zeta potential of -20.7 mV. The differential scanning calorimetry (DSC) analysis indicated that silybin was not in crystalline state in the NLC. In vitro data for release of the drug from silybin-NLC was fitted to a two-stage exponential kinetic model. The pharmacokinetics and tissue distribution of silybin-NLC were studied after intravenous administration using New Zealand rabbits and Kunming mice as experimental animals. A silybin control solution was studied parallelly. Silybin-NLC showed higher AUC (area under tissue concentration-time curve) values and circulated in the blood stream for a longer time compared with silybin solution. The tissue distribution demonstrated a high uptake of silybin-NLC in RES organs particularly in liver. These results indicate that NLC is a potential sustained release and targeting system for silybin.

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Citations

Dec 4, 2013·Journal of Agricultural and Food Chemistry·Urszula LewandowskaSylwia Gorlach
Mar 25, 2014·Colloids and Surfaces. B, Biointerfaces·Leilei HaoQiang Zhang
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