Nanostructured platforms for the sustained and local delivery of antibiotics in the treatment of osteomyelitis

Critical Reviews in Therapeutic Drug Carrier Systems
Vuk Uskoković

Abstract

This article provides a critical view of the current state of the development of nanoparticulate and other solid-state carriers for the local delivery of antibiotics in the treatment of osteomyelitis. Mentioned are the downsides of traditional means for treating bone infection, which involve systemic administration of antibiotics and surgical debridement, along with the rather imperfect local delivery options currently available in the clinic. Envisaged are more sophisticated carriers for the local and sustained delivery of antimicrobials, including bioresorbable polymeric, collagenous, liquid crystalline, and bioglass- and nanotube-based carriers, as well as those composed of calcium phosphate, the mineral component of bone and teeth. A special emphasis is placed on composite multifunctional antibiotic carriers of a nanoparticulate nature and on their ability to induce osteogenesis of hard tissues demineralized due to disease. An ideal carrier of this type would prevent the long-term, repetitive, and systemic administration of antibiotics and either minimize or completely eliminate the need for surgical debridement of necrotic tissue. Potential problems faced by even hypothetically "perfect" antibiotic delivery vehicles are me...Continue Reading

Citations

Dec 27, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Nenad IgnjatovićDragan Uskoković
Sep 12, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Vuk Uskoković
Apr 30, 2016·Materials Science & Engineering. C, Materials for Biological Applications·V C C TrajanoM E Cortés
May 24, 2015·International Journal of Pharmaceutics·Ana C MatosAna F Bettencourt
May 24, 2016·Biochimica Et Biophysica Acta·Victoria M Wu, Vuk Uskoković
Jun 28, 2016·Materials·Vuk Uskoković, Victoria M Wu
Nov 4, 2017·Tissue Engineering. Part a·Jan GessmannManfred Köller
Jan 16, 2020·Brazilian Oral Research·Vivianne Carvalho da Cunha TrajanoMaria Esperanza Cortés
Sep 26, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Vuk UskokovićVictoria M Wu
Nov 5, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Vuk Uskoković
Jan 16, 2020·Foundations of Science·Victoria Wu, Vuk Uskoković
Nov 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Vuk UskokovićVictoria M Wu
Jun 2, 2020·Drug Development and Industrial Pharmacy·Behrad GhiasiVuk Uskoković
Apr 10, 2020·Advanced Biosystems·Jacklyn WhiteheadJ Kent Leach
Oct 3, 2020·Advances in Colloid and Interface Science·Marcel F KunrathMaría E Galárraga-Vinueza
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·R HanP J Walsh
Sep 3, 2020·British Journal of Pharmacology·Shuting SunFrank H Ebetino
Sep 19, 2018·ACS Applied Materials & Interfaces·Victoria M WuVuk Uskoković
Nov 11, 2021·Drug Delivery·Reem Khaled WassifSeham A Elkheshen
Dec 16, 2021·Artificial Cells, Nanomedicine, and Biotechnology·Muhammad Usman MunirFarooq Aziz

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