Nanostructured Polymer Thin Films Fabricated with Brush-based Layer-by-Layer Self-assembly for Site-selective Construction and Drug release

Scientific Reports
Kyungtae ParkJinkee Hong

Abstract

Layer-by-Layer (LbL) self-assembly has been investigated for several decades. However, the conventional LbL method has performance problems on the chair-side caused by its cumbersome and time-consuming process. Thus, we investigate a new LbL self-assembly technique for the fast and high efficient preparation process based on the brush. The multilayer films fabricated by simple sequential brushing of polyelectrolyte solutions are compared to the classical dipping method. We characterize the multilayer films by characteristics such as their morphology and thickness, and compare them against those of the classic method by profilometry, atomic force microscopy. We prepare multilayer films with biocompatible polyelectrolytes, chitosan, and alginate incorporated with a hydrophobic drug carrier. For the drug carrier, a poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-b-PCL) block copolymer is introduced to construct micelles containing dexamethasone, which is a well-known osteogenesis-inducing drug. The hydrogen bonding behavior between adjacent layers and micelles is investigated by Fourier transform infrared spectroscopy. Additionally, we analyze the release profiles, degradation profiles and toxicity of the multilayer films fo...Continue Reading

References

Jan 1, 1994·Journal of Biomaterials Science. Polymer Edition·K BergströmJ H Harris
Mar 18, 1994·Science·R GrefR Langer
Jun 19, 2001·Journal of Biomedical Materials Research·X L YanL Y Lim
Mar 12, 2003·Advanced Drug Delivery Reviews·Hidenori OtsukaKazunori Kataoka
Aug 24, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Hyong-Jun KimJinsang Kim
Mar 29, 2007·Chemical Communications : Chem Comm·Xi ZhangHongyu Zhang
May 8, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Diego A Chiappetta, Alejandro Sosnik
Jun 27, 2007·Biomacromolecules·Gwen LawrieLisbeth Grøndahl
Nov 17, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Weiyong YuanQin Zhou
Apr 23, 2011·Advanced Drug Delivery Reviews·Katsuhiko ArigaJonathan P Hill
Mar 7, 2014·Journal of Colloid and Interface Science·Marcos CoustetSergio E Moya
Aug 3, 2014·Journal of Colloid and Interface Science·João Paulo Campos TrigueiroRodrigo Lassarote Lavall
Apr 25, 2015·Science·Joseph J RichardsonFrank Caruso
Nov 13, 2015·ACS Applied Materials & Interfaces·Hyejoong JeongJinkee Hong
May 14, 2016·ACS Applied Materials & Interfaces·Ruiyun ZhangXuehai Yan
Mar 14, 2016·ACS Biomaterials Science & Engineering·Hyejoong JeongJinkee Hong

❮ Previous
Next ❯

Citations

Aug 9, 2018·Chemical Communications : Chem Comm·Jong Keun ParkPhillip D Hustad
May 3, 2020·Polymers·Agata Krywko-CendrowskaWolfgang Meier
Jun 6, 2018·International Journal of Molecular Sciences·Shichao ZhangBingyun Li
Jan 4, 2021·Chemosphere·Claudiu-Augustin Ghiorghita, Marcela Mihai
Aug 8, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Miryam Criado-GonzalezRebeca Hernández

❮ Previous
Next ❯

Methods Mentioned

BETA
atomic
quartz crystal microbalance
Dynamic Light Scattering
AFM
infrared spectroscopy
Quartz

Software Mentioned

ImageJ

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.