Nanostructured reverse hexagonal liquid crystals sustain plasma concentrations for a poorly water-soluble drug after oral administration

Drug Delivery and Translational Research
Tri-Hung NguyenBen J Boyd

Abstract

Reverse hexagonal (H2) liquid crystals formed from selachyl alcohol were demonstrated to sustain the absorption of the poorly water-soluble drug cinnarizine (CZ) after oral administration to rats. When CZ was administered as a bolus lipid solution in selachyl alcohol, the T max was observed to be 23.5 ± 5.9 h, significantly longer than the control suspension (1 h). Administration of selachyl alcohol as dispersed nanoparticles (hexosomes) also resulted in a sustained plasma profile, with drug concentrations maintained from 20 to 40 ng/mL over the first 24 h after administration. Sustained absorption of CZ from the selachyl alcohol hexosomes led to a significant enhancement (p < 0.05) in oral bioavailability (F% = 17%) compared to the control CZ suspension (9%). Analysis of selachyl alcohol hexosomes using small-angle x-ray scattering indicated that neither the presence of CZ (7 mg/g) nor simulated intestinal fluid altered the H2 nanostructure. Selachyl alcohol is not susceptible to digestion. Prolonged absorption from the selachyl alcohol-based H2 systems was attributed to the non-digestible nature of the lipid, similar to non-digestible phytantriol cubic (V2) systems previously reported. Furthermore, the likely presence of non-...Continue Reading

References

Feb 1, 1987·Journal of Pharmaceutical Sciences·P GruberJ R Robinson
Oct 31, 1998·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·L S NielsenJ Hansen
Mar 2, 1999·Journal of Colloid and Interface Science·J GustafssonH Ljusberg-Wahren
Apr 20, 2001·Advanced Drug Delivery Reviews·J C ShahD M Chilukuri
May 24, 2001·The Journal of Pharmacy and Pharmacology·J LeeI W Kellaway
Jan 5, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Narushi TakamatsuGordon L Amidon
Apr 27, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Al-Sayed SallamIbtisam Freij
Sep 3, 2002·International Journal of Pharmaceutics·Britta SiekmannKirsten Westesen
Jul 5, 2003·International Journal of Pharmaceutics·Ben J Boyd
Dec 31, 1956·Acta Physiologica Scandinavica·S BERGSTROM, R BLOMSTRAND
Apr 1, 1959·Proceedings of the Society for Experimental Biology and Medicine·R BLOMSTRAND, E H AHRENS
Jun 18, 1963·Biochimica Et Biophysica Acta·A F HOFMANN
Mar 23, 2004·Pharmaceutical Research·Ann Marie KaukonenWilliam N Charman
Jul 21, 2004·Colloids and Surfaces. B, Biointerfaces·Warunee LeesajakulTetsurou Handa
Sep 24, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Greg A KossenaChristopher J H Porter
Apr 9, 2005·International Journal of Pharmaceutics·Manish H Shah, Anant Paradkar
Nov 4, 2005·Pharmaceutical Research·Elisabetta EspositoCarmelo Puglia
Apr 20, 2006·International Journal of Pharmaceutics·Ben J BoydGreg Davey
Feb 6, 2007·Journal of Colloid and Interface Science·Dima LibsterNissim Garti
Sep 11, 2007·Pharmaceutical Research·Nitin K SwarnakarN K Jain
Apr 19, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tri-Hung NguyenBen J Boyd

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Citations

Feb 5, 2014·Expert Opinion on Drug Delivery·Alexandre LancelotJosé Luis Serrano
Dec 15, 2012·Journal of Colloid and Interface Science·Xavier MuletCalum J Drummond
Sep 4, 2015·Drug Delivery and Translational Research·Anna C PhamBen J Boyd
May 26, 2015·International Journal of Pharmaceutics·Jong-Lae LimEun-Seok Park
Sep 14, 2016·Journal of Colloid and Interface Science·Wye-Khay FongBen J Boyd
Oct 30, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Rokhsana YasminClive Prestidge
Feb 13, 2018·BioImpacts : BI·Muhammad Nuh MusaRajan Rajabalaya
Apr 10, 2019·Nature Nanotechnology·Livia Salvati ManniRaffaele Mezzenga
Sep 17, 2020·Drug Delivery and Translational Research·Gisela RamirezBen J Boyd
Mar 7, 2021·Drug Delivery and Translational Research·Chelsea R ThornClive A Prestidge
Feb 24, 2021·AAPS PharmSciTech·Xingwang Zhang, Wei Wu
Jun 29, 2021·Frontiers in Cell and Developmental Biology·Anna C PhamBen J Boyd
Jul 27, 2021·Journal of Colloid and Interface Science·Younus MohammadShakila B Rizwan

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