Nanostructured surface topographies have an effect on bactericidal activity

Journal of Nanobiotechnology
Songmei WuQun Ren

Abstract

Due to the increased emergence of antimicrobial resistance, alternatives to minimize the usage of antibiotics become attractive solutions. Biophysical manipulation of material surface topography to prevent bacterial adhesion is one promising approach. To this end, it is essential to understand the relationship between surface topographical features and bactericidal properties in order to develop antibacterial surfaces. In this work a systematic study of topographical effects on bactericidal activity of nanostructured surfaces is presented. Nanostructured Ormostamp polymer surfaces are fabricated by nano-replication technology using nanoporous templates resulting in 80-nm diameter nanopillars. Six Ormostamp surfaces with nanopillar arrays of various nanopillar densities and heights are obtained by modifying the nanoporous template. The surface roughness ranges from 3.1 to 39.1 nm for the different pillar area parameters. A Gram-positive bacterium, Staphylococcus aureus, is used as the model bacterial strain. An average pillar density at ~ 40 pillars μm-2 with surface roughness of 39.1 nm possesses the highest bactericidal efficiency being close to 100% compared with 20% of the flat control samples. High density structures at ~ 7...Continue Reading

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Citations

Jul 25, 2019·Critical Reviews in Biotechnology·Guangshun YiYugen Zhang
Nov 26, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Juergen TaxisTobias Moest
Sep 27, 2019·Materials·Karin SchwibbertJörg Krüger
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Sep 4, 2020·Micromachines·Tianyu Mao, Fengzhou Fang
Oct 24, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guangshun YiYugen Zhang
Dec 18, 2020·Frontiers in Bioengineering and Biotechnology·Jianqiao LiuYujin Tang
Jun 21, 2021·Colloids and Surfaces. B, Biointerfaces·Qianqian CuiDan Ge
Sep 26, 2019·The Journal of Physical Chemistry. B·Tianqing LiuShui Guan
Sep 9, 2019·ACS Biomaterials Science & Engineering·Sevde AltuntasMansoor Amiji
Sep 30, 2021·Scientific Reports·Nobuaki NegishiSetsuko Koura
Jan 7, 2022·Langmuir : the ACS Journal of Surfaces and Colloids·Zhe ChenYu Liu

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Methods Mentioned

BETA
fluorescence microscopy
AFM

Software Mentioned

OrmoStamp

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