Nanostructured titanium regulates osseointegration via influencing macrophage polarization in the osteogenic environment

International Journal of Nanomedicine
Jinjin WangYumei Zhang

Abstract

Fabricating nanostructured surface topography represents the mainstream approach to induce osteogenesis for the next-generation bone implant. In the past, the bone implant was designed to minimize host repulsive reactions in order to acquire biocompatibility. However, increasing reports indicate that the absence of an appropriate immune response cannot acquire adequate osseointegration after implantation in vivo. We prepared different topographies on the surface of titanium (Ti) specimens by grinding, etching and anodizing, and they were marked as polished specimen (P), specimen with nanotubes (NTs) in small diameters (NT-30) and specimen with NTs in large diameters (NT-100). We evaluated the ability of different topographies of the specimen to induce osteogenic differentiation of mice bone marrow mesenchymal stem cells (BMSCs) in vitro and to induce osseointegration in vivo. Furthermore, we investigated the effect of different topographies on the polarization and secretion of macrophages, and the effect of macrophage polarization on topography-induced osteogenic differentiation of mice BMSCs. Finally, we verified the effect of macrophage polarization on topography-induced osseointegration in vivo by using Cre*RBP-Jfl/fl mice i...Continue Reading

Citations

Jun 6, 2019·Annual Review of Biomedical Engineering·Nikhil JainViola Vogel
Mar 13, 2020·Biomaterials Science·Jefferson O AbariciaRene Olivares-Navarrete
Jun 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hongxuan QuanHyeong-Cheol Yang
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Methods Mentioned

BETA
flow cytometry
protein array
AFM

Software Mentioned

NIH ImageJ
GraphPad
ImageJ
VGStudio Max
GraphPad Prism

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