Nanostructures of an amphiphilic zinc phthalocyanine polymer conjugate for photodynamic therapy of psoriasis

Colloids and Surfaces. B, Biointerfaces
Yiguang JinMiao Li

Abstract

Psoriasis is a chronic inflammatory skin disease affecting 2-5% of the population worldwide and it severely affects patient quality of life. In this study, an amphiphilic zinc phthalocyanine polymer conjugate (ZPB) was synthesized, in which zinc phthalocyanine (ZnPc) was conjugated with the poly(ethylene glycol) (PEG) chain of Brij 58. ZPB showed two maximum UV-vis absorption wavelengths, 348 nm and 678 nm. A monomolecular micelle of ZPB formed in water with a mean size of 25 nm and zeta potential of -15 mV. The nanostructures aggregated into cloudy precipitates, which were easily dispersed. The nanostructure showed the shell-core structure with the ZnPc segments as the core and the PEG chains as the shell. The anti-psoriasis effect of the ZPB nanostructure was explored using a guinea pig psoriasis model. After comparing the anti-psoriasis effects of saline, light alone, ZPB alone, and the combination of light and ZPB, the combination of light and ZPB showed the best photodynamic therapy of psoriasis based on the light excitation of the photosensitizer ZPB and the psoriasis was nearly cured according to the histopathological investigation. The ZPB nanostructure is a promising anti-psoriasis nanomedicine based on photodynamic th...Continue Reading

References

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Citations

Sep 26, 2015·International Journal of Molecular Sciences·Miri KimHyun Jeong Park
Jan 24, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Canan UslanB Sebnem Sesalan
Apr 17, 2019·The Journal of Dermatological Treatment·Wei ZhaoHong-Qing Tian
Jan 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Miguel Á Revuelta-MazaTomás Torres
Aug 11, 2019·International Journal of Molecular Sciences·Sarah Raquel De AnnunzioCarla Raquel Fontana
Jul 2, 2019·Current Pharmaceutical Design·Marcos L BruschiHélen C Rosseto
Apr 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Clinton GomezPranee Rojsitthisak
May 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daiana K DedaCelia R S Garcia
Dec 12, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yijun MeiMin Ren
Dec 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valéria VerebováJana Staničová
Aug 14, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Madhulika Pradhan Ajazuddin
May 4, 2021·Photodiagnosis and Photodynamic Therapy·Dan YangHongxia Dan
Jan 30, 2020·Current Drug Safety·Harman BakshiGeeta Aggarwal
Jul 11, 2018·Bioconjugate Chemistry·Okhil K NagJames B Delehanty
Sep 26, 2021·AAPS PharmSciTech·Sudeep Sudesh PukaleDeepak Chitkara

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