Nanostructures of complexes formed by calf thymus DNA interacting with cationic surfactants

Biomacromolecules
Shuiqin ZhouBenjamin Chu

Abstract

Synchrotron small-angle X-ray scattering was used to study the nanostructures of the complexes formed by calf thymus DNA interacting with cationic lipids (or surfactants) of didodecyldimethylammonium bromide (DDAB), cetyltrimethylammonium bromide (CTAB), and their mixture with a zwitterionic lipid of 1-palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine (PHGPC). The effects of lipid/DNA ratios, DNA chain flexibility, lipid topology, and neutral lipid mixing on the nanostructures of DNA-lipid complexes were investigated. The complexes between double-stranded DNA (dsDNA) and double-tailed DDAB formed a bilayered lamellar structure, whereas the complexes between dsDNA and single-tailed CTAB preferred a structure of 2D hexagonal close packing of cylinders. With single stranded DNA (ssDNA) interacting with CTAB, the complexes showed a Pm3n cubic structure due to the different chain flexibility between dsDNA and ssDNA. The lipid molecules bound by rigid dsDNA like to form cylindrical micelles, whereas lipids bound to flexible ssDNA could form spherical or short cylindrical micelles. The addition of the neutral single-chained PHGPC lipids to the CTAB lipids could induce a structural transition of dsDNA-lipid complexes from a 2D hexagonal ...Continue Reading

References

Jul 2, 1998·Biophysical Journal·D HarriesA Ben-Shaul
Mar 29, 2000·Biophysical Journal·S MayA Ben-Shaul
Apr 20, 2001·Advanced Drug Delivery Reviews·M C Pedroso de LimaN Düzgüneş

❮ Previous
Next ❯

Citations

May 9, 2012·Chemistry of Materials : a Publication of the American Chemical Society·Aaron M Lowe, Nicholas L Abbott
Aug 13, 2009·The Journal of Physical Chemistry. B·Alexandra ZidovskaCyrus R Safinya
Nov 21, 2008·Chemical Society Reviews·XiangDong LiuNorio Nishi
Aug 12, 2009·Molecular BioSystems·Kazunori MatsuuraNobuo Kimizuka
Aug 20, 2010·Physical Chemistry Chemical Physics : PCCP·Fen WanBenjamin Chu
May 12, 2009·Journal of Bacteriology·Sarah R SchoolingTerry J Beveridge
Dec 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Kai LiuAndreas Herrmann
Apr 6, 2011·Journal of Colloid and Interface Science·Yunfei HeYing Hu
Oct 22, 2008·Advances in Colloid and Interface Science·Dominique Langevin
May 30, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Peicai LiErkang Wang
May 28, 2009·Chemistry : a European Journal·Angelo Perico, Alberto Ciferri
Jul 27, 2007·The Journal of Gene Medicine·Shawn D WettigMarianna Foldvari
Oct 11, 2007·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Siwar TrabelsiDominique Langevin
Jun 16, 2011·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Matthias DittrichGerald Brezesinski
Oct 27, 2011·Angewandte Chemie·Christopher M JewellDarrell J Irvine
Sep 12, 2013·Small·Ronit BittonSamuel I Stupp
May 2, 2014·Molecular Microbiology·Mery PinaDavid Prangishvili
Feb 26, 2015·Chemistry : a European Journal·Kai LiuAndreas Herrmann
Nov 23, 2006·Colloids and Surfaces. B, Biointerfaces·Christian Burger, Benjamin Chu
Oct 7, 2006·International Journal of Biological Macromolecules·Naoki SasakiAkimasa Fukui
Aug 16, 2006·FEMS Microbiology Letters·Uta BöckelmannUlrich Szewzyk
Jul 8, 2017·Chemical Society Reviews·Kai LiuAndreas Herrmann
Nov 11, 2019·International Journal of Molecular Sciences·Weronika AndrzejewskaMaciej Kozak
Jan 4, 2013·Chemical Communications : Chem Comm·Yuanyuan CaoShunai Che
Nov 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ricardo GasparBruno F B Silva
Jun 28, 2008·The Journal of Physical Chemistry. B·Vaibhav M JadhavSouvik Maiti
Dec 23, 2008·Biomacromolecules·Wirasak SmitthipongMatthew Tirrell
Sep 1, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Matthias DittrichChristian Wölk
Jun 14, 2006·Biomacromolecules·Tatsuya KawashimaShigeo Sasaki
May 24, 2007·Biomacromolecules·Paola LucianiPaavo K J Kinnunen
Oct 7, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Wei-Long HsuWen-Liang Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.