Nanotechnology in Tuberculosis: State of the Art and the Challenges Ahead

Pharmaceutical Research
Estefania GrotzMarcela A Moretton

Abstract

Tuberculosis (TB) remains as the second most-deadly infection right behind the HIV/AIDS. Actually, in 2016, TB incidence was estimated in 10.4 million cases. Although an efficient and low-cost TB pharmacotherapy has been available for the last 50 years, the development of multi- and extra-drug-resistant Mycobacterium tuberculosis (Mtb) strains has put on the spot the necessity of improved TB regimens. In this framework, this review article presents the main relevant research outcomes of nanotechnology in TB. The novel delivery systems for antituberculosis drugs have been discussed. Moreover, the active-targeted nanomedicines to the Mtb reservoirs enlighten the possibility to eradicate low-replicant mycobacteria and diminish latent TB. Finally, we present an overview of the TB socio-economic impact and the cost-related features of TB regimens associated with the use of nanoformulations.

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Citations

Jun 19, 2019·Current Pharmaceutical Biotechnology·Jyoti YadavRanjana Jaiwal
Mar 13, 2019·Pharmaceutical Research·Admire Dube
Jul 14, 2020·Future Microbiology·Zsuzsa Baranyai
Dec 29, 2020·Journal of Microbiological Methods·Madushani H Dahanayake, Anil C A Jayasundera
Oct 30, 2020·International Journal of Nanomedicine·Qiuzhen LiangXinghua Song
Apr 23, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jaskiran KaurKuppusamy Gowthamarajan

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Methods Mentioned

BETA
pharmacotherapy

Clinical Trials Mentioned

NCT02454205
NCT02409290
NCT03086486
NCT02193776

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