Nanotemplate-engineered nanoparticles containing gadolinium for magnetic resonance imaging of tumors

Investigative Radiology
Donghua ZhuMichael Jay

Abstract

To design nanoparticles containing accessible gadolinium atoms (Gd-NPs) as a contrast agent for magnetic resonance imaging of tumors. Nanoparticles containing phospholipid-chelates (phosphoethanolamine diethylenetriaminepentaacetate) and DSPE-PEG (MW5000) were prepared from Brij 78 and stearyl alcohol using the nanotemplate engineering approach. After addition of GdCl3, the presence of gadolinium on the surface of nanoparticles was quantified using inductively coupled plasma atomic emission spectroscopy. The in vitro relaxivities of the Gd-NPs in phosphate buffered saline were assessed at 4.7 T. The conditional binding constants of nanoparticle formulations were determined spectrophotometrically by competitive titration. Transmetallation kinetics of Gd from nanoparticles with Cu2+ and Zn2+ as the competing ions was measured in acetate buffer. The biodistribution profiles, pharmacokinetics, and contrast enhancement in tumor region was studied after administration of Gd-NPs to nude mice bearing A549 lung carcinoma xenografts. Gd-NPs with an average diameter of 138 nm possessing surface chelating functions were prepared from GRAS (generally regarded as safe) materials. The longitudinal relaxivity (r1) and transverse relaxivity (r2...Continue Reading

References

Sep 1, 1991·British Journal of Pharmacology·J MolgóD Angaut-Petit
Dec 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R C Brasch
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D PapahadjopoulosC Redemann
Sep 30, 1991·Biochimica Et Biophysica Acta·T M Allen, C Hansen
Jan 1, 1990·Magnetic Resonance Imaging·W P CacherisS M Rocklage
Sep 1, 1990·The American Journal of Physiology·B A Biagi, J J Enyeart
Jan 1, 1990·Journal of Microencapsulation·W G LoveI W Kellaway
Dec 1, 1988·Biological Trace Element Research·A Favier, D Ruffieux
Nov 1, 1989·The Journal of Nutrition·W R Harris, C Keen
Apr 1, 1989·Radiology·C TilcockP MacDougall
Oct 1, 1988·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A D SherryK T Kuan
Sep 1, 1972·Biochimica Et Biophysica Acta·N Krasnow
Mar 1, 1984·AJR. American Journal of Roentgenology·H J WeinmannG E Wesbey
Oct 12, 1994·Biochimica Et Biophysica Acta·V P TorchilinC A Gentry
Nov 1, 1995·Journal of Magnetic Resonance Imaging : JMRI·R W StorrsK C Li
Mar 17, 1999·Journal of Magnetic Resonance Imaging : JMRI·L H BryantJ A Frank
Jun 24, 2000·Proceedings of the Society for Experimental Biology and Medicine·D J Rowe, D J Bobilya
Aug 1, 2000·Colloids and Surfaces. B, Biointerfaces·V WeissigV Torchilin
Jul 27, 2001·Current Pharmaceutical Biotechnology·V P Torchilin
Sep 11, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H KobayashiM W Brechbiel
Dec 18, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·N SatoM W Brechbiel
Mar 14, 2002·Nuclear Medicine Communications·R J Baker
Mar 21, 2002·Journal of the American Chemical Society·Peter CaravanRandall B Lauffer
Nov 14, 2002·Bioscience Reports·Kazuo Maruyama
Mar 5, 2003·Circulation·Samuel A Wickline, Gregory M Lanza
Apr 19, 2003·Journal of Colloid and Interface Science·Véronique M SadtlerEdith Dellacherie
Sep 23, 2003·Advanced Drug Delivery Reviews·Paolo Caliceti, Francesco M Veronese
Oct 3, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hisataka KobayashiMartin W Brechbiel
Jan 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sean C L DeoniBrian K Rutt
Mar 17, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Moses O OyewumiRussell J Mumper
Sep 17, 2004·Chemistry : a European Journal·Luca FrullanoJoop A Peters
Nov 5, 2004·Ernst Schering Research Foundation Workshop·S AimeL Tei
Mar 10, 2005·JAMA : the Journal of the American Medical Association·Joann G ElmoreSuzanne W Fletcher

❮ Previous
Next ❯

Citations

Apr 28, 2010·Biomacromolecules·Lindsay S Karfeld-SulzerAnnelise E Barron
Jul 24, 2008·Contrast Media & Molecular Imaging
Feb 4, 2012·Journal of the American College of Cardiology·Karen C Briley-SaeboSotirios Tsimikas
Dec 15, 2010·Investigative Radiology·John N MorelliMichael Tweedle
Apr 13, 2010·Investigative Radiology·Val M Runge
Nov 13, 2008·Investigative Radiology·Val M Runge
Jul 27, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Melissa D HowardThomas D Dziubla
Dec 31, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Melissa D HowardThomas D Dziubla

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.