Nanotherapy and Reactive Oxygen Species (ROS) in Cancer: A Novel Perspective

Antioxidants
Peter Brenneisen, Andreas S Reichert

Abstract

The incidence of numerous types of cancer has been increasing over recent years, representing the second-most frequent cause of death after cardiovascular diseases. Even though, the number of effective anticancer drugs is increasing as well, a large number of patients suffer from severe side effects (e.g., cardiomyopathies) caused by these drugs. This adversely affects the patients' well-being and quality of life. On the molecular level, tumor cells that survive treatment modalities can become chemotherapy-resistant. In addition, adverse impacts on normal (healthy, stromal) cells occur concomitantly. Strategies that minimize these negative impacts on normal cells and which at the same time target tumor cells efficiently are needed. Recent studies suggest that redox-based combinational nanotherapies may represent one option in this direction. Here, we discuss recent advances in the application of nanoparticles, alone or in combination with other drugs, as a promising anticancer tool. Such novel strategies could well minimize harmful side effects and improve patients' health prognoses.

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Citations

Aug 1, 2018·Antioxidants·Claus Jacob
Aug 9, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Maonan WangJiahua Zhou
Nov 19, 2019·Mini Reviews in Medicinal Chemistry·Natalia ForbotKatarzyna Roszek
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Feb 16, 2020·Experimental & Molecular Medicine·Bruno PerilloAntimo Migliaccio
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Jul 11, 2021·Cellular Oncology (Dordrecht)·Michelle van der MerweAnna-Mart Engelbrecht
Nov 15, 2018·ACS Applied Materials & Interfaces·Joungyoun NohDongwon Lee

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Methods Mentioned

BETA
xenograft

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