Nanotopography facilitates in vivo transdermal delivery of high molecular weight therapeutics through an integrin-dependent mechanism

Nano Letters
Laura A WalshTejal A Desai

Abstract

Transdermal delivery of therapeutics is restricted by narrow limitations on size and hydrophobicity. Nanotopography has been shown to significantly enhance high molecular weight paracellular transport in vitro. Herein, we demonstrate for the first time that nanotopography applied to microneedles significantly enhances transdermal delivery of etanercept, a 150 kD therapeutic, in both rats and rabbits. We further show that this effect is mediated by remodeling of the tight junction proteins initiated via integrin binding to the nanotopography, followed by phosphorylation of myosin light chain (MLC) and activation of the actomyosin complex, which in turn increase paracellular permeability.

References

Dec 1, 1993·The Journal of Cell Biology·M FuruseS Tsukita
Jan 1, 1995·Annual Review of Cell and Developmental Biology·B M JockuschJ Winkler
Jan 1, 1996·Annual Review of Cell and Developmental Biology·E Ruoslahti
Apr 4, 2000·The Journal of Cell Biology·S Tsukita, M Furuse
Sep 26, 2000·American Journal of Physiology. Cell Physiology·J H TinsleyS Y Yuan
Apr 20, 2004·Experimental Cell Research·Matthew J DalbyAdam S G Curtis
Jul 21, 2004·European Journal of Cell Biology·Matthew J DalbyAdam S G Curtis
Jun 1, 2005·Medical Engineering & Physics·Matthew J Dalby
Mar 4, 2006·Biophysical Journal·Achim Besser, Samuel A Safran
Sep 25, 2007·Advanced Drug Delivery Reviews·Biana Godin, Elka Touitou
Mar 29, 2008·Methods in Molecular Biology·Marc B BrownFranklin K Akomeah
Jun 14, 2008·Biomaterials·Jiyeon LeeTanmay P Lele
Mar 26, 2009·IUBMB Life·Mary K Findley, Michael Koval
Jun 10, 2009·The Journal of Pharmacy and Pharmacology·Rekha Rao, Sanju Nanda
Feb 9, 2010·Nanomedicine : Nanotechnology, Biology, and Medicine·Manus Jonathan Paul BiggsMatthew J Dalby
Aug 25, 2010·European Journal of Cell Biology·Nina KirschnerJohanna M Brandner
Aug 14, 2012·Experimental Dermatology·Anna CelliTheodora M Mauro
Jan 25, 2013·Molecular Therapy. Nucleic Acids·Kate E BroderickNiranjan Y Sardesai
Mar 16, 2013·Current Pharmaceutical Design·Mahmoud Elsabahy, Marianna Foldvari

❮ Previous
Next ❯

Citations

Oct 30, 2015·Expert Opinion on Drug Delivery·Laura A WalshTejal A Desai
Aug 6, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cade B FoxTejal A Desai
Mar 22, 2016·Pharmaceutics·Kevin Ita
Oct 20, 2015·ACS Applied Materials & Interfaces·Kunwoo LeeHongyun So
Aug 1, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiangfei HanZhiqiang Cao
Nov 17, 2019·Journal of Personalized Medicine·Liliana R PiresJoão Gaspar
Jun 2, 2017·Arthritis Research & Therapy·Melissa B AldrichE M Sevick-Muraca
Nov 7, 2019·Nature Biomedical Engineering·Nicholas G LamsonKathryn A Whitehead
Jan 6, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Andi Dian PermanaRyan F Donnelly
Jan 10, 2021·Pharmaceutics·Daniela Placha, Josef Jampilek
Oct 29, 2020·Cancer Gene Therapy·Jonathan BrionesMasato Saito
May 31, 2021·Advanced Drug Delivery Reviews·Zhi LuoJean-Christophe Leroux
May 12, 2020·Biochimica Et Biophysica Acta. Biomembranes·K Sabrina LynnMichael Koval

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Annals of the New York Academy of Sciences
Kevin E Cunningham, Jerrold R Turner
Harefuah
E Touitou, E Menczel
Journal of the American Animal Hospital Association
Steven L Marks, Joseph Taboada
© 2021 Meta ULC. All rights reserved