Nanotopography-Promoted Formation of Axon Collateral Branches of Hippocampal Neurons

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Jeongyeon SeoInsung S Choi

Abstract

Axon collateral branches, as a key structural motif of neurons, allow neurons to integrate information from highly interconnected, divergent networks by establishing terminal boutons. Although physical cues are generally known to have a comprehensive range of effects on neuronal development, their involvement in axonal branching remains elusive. Herein, it is demonstrated that the nanopillar arrays significantly increase the number of axon collateral branches and also promote their growth. Immunostaining and biochemical analyses indicate that the physical interactions between the nanopillars and the neurons give rise to lateral filopodia at the axon shaft via cytoskeletal changes, leading to the formation of axonal branches. This report, demonstrates that nanotopography regulates axonal branching, and provides a guideline for the design of sophisticated neuron-based devices and scaffolds for neuro-engineering.

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Citations

Jan 21, 2020·Advanced Healthcare Materials·Beom Jin KimInsung S Choi
Aug 28, 2019·Nanoscale·Isabel M BjørgeJoão F Mano
Apr 19, 2020·Developmental Neurobiology·Jeongyeon SeoInsung S Choi
Aug 21, 2020·Advanced Healthcare Materials·Jeongyeon SeoInsung S Choi
Nov 17, 2020·Frontiers in Bioengineering and Biotechnology·Claire Leclech, Catherine Villard
Apr 20, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Akshay JoshiNeetu Singh
Jun 23, 2021·Acta Biomaterialia·Seokyoung BangHong Nam Kim
Aug 27, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Seulbi KimJi Hun Park
Feb 15, 2020·ACS Applied Materials & Interfaces·Ya-Qiong ZhangBo Zhu
Sep 24, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Hee Chul MoonInsung S Choi

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