Nanovolume Gas-Free Hydroxide Eluent Generator for Open Tubular Ion Chromatography

Analytical Chemistry
Bikash ChouhanPurnendu K Dasgupta

Abstract

A gas-free KOH eluent generator (EG) with 210 nL of internal volume is described. It utilizes a two-membrane configuration where there is a single CEM layer on one side and a single BPM layer on the other side for use in open tubular ion chromatography systems with typical back pressures < 50 psi. At a flow rate of ∼190 nL/min, the 10-90% gradient rise time is 3.5 min. The device shows good linearity between applied current and concentration of KOH generated, which is stable over extended periods. The overall system reproducibility (that includes contributions from any changes in flow rate), as judged by the relative standard deviation (RSD) of the retention times of individual separated ions in repeat measurements (n = 6), ranged from <0.5% for isocratic to <1.2% for gradient elution schemes. Perceptible current flow and KOH production in the BPM-based EG begins at subelectrolytic applied voltages, prompting us to look more closely at exact field strength necessary for field-enhanced dissociation of water. An increase in the specific conductance of pure water is noticeable by a field strength of 105 V/m.

References

May 1, 2004·Analytical Chemistry·Petr KubanPurnendu K Dasgupta
Sep 4, 2004·Journal of Biochemical and Biophysical Methods·Yan LiuNebojsa Avdalovic
Dec 8, 2007·Analytical Chemistry·Bingcheng YangPurnendu K Dasgupta
Jan 31, 2009·Journal of Chromatography. a·Bingcheng YangPurnendu K Dasgupta
Jun 1, 1998·Analytical Chemistry·H Small, J Riviello
Nov 14, 2014·Analytical Chemistry·Bingcheng YangPurnendu K Dasgupta
Feb 15, 2017·Analytical Chemistry·Weixiong Huang, Purnendu K Dasgupta
Feb 15, 2017·Analytical Chemistry·Weixiong HuangPurnendu K Dasgupta
Apr 8, 2018·Journal of Chromatography. a·Weixiong HuangPurnendu K Dasgupta
Oct 3, 2018·Analytical Chemistry·Yifei LuFeifang Zhang
Nov 23, 2018·Analytical Chemistry·Weixiong HuangPurnendu K Dasgupta
Mar 12, 2019·Journal of Chromatography. a·Shujun HuangBingcheng Yang
Jul 31, 2019·Talanta·Purnendu K Dasgupta, Fereshteh Maleki

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Citations

Dec 29, 2020·Journal of Chromatography. a·Shuai LiuMin Zhang
Jan 2, 2021·Analytica Chimica Acta·Weixiong Huang
Jan 17, 2021·Journal of Chromatography. a·Joshua J DavisJames P Grinias
Mar 25, 2021·Analytical Chemistry·Charles Phillip ShelorPurnendu K Dasgupta
Aug 31, 2020·Analytical Chemistry·Fereshteh Maleki, Purnendu K Dasgupta

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