Nanowire lasers as intracellular probes

Nanoscale
Xiaoqin WuXudong Fan

Abstract

We investigate a cadmium sulfide (CdS) nanowire (NW) laser that is spontaneously internalized into a single cell to serve as a stand-alone intracellular probe. By pumping with nano-joule light pulses, green laser emission (500-520 nm) can be observed inside cells with a peak linewidth as narrow as 0.5 nm. Due to the sub-micron diameter (∼200 nm), the NW has an appreciable fraction of the evanescent field outside, facilitating a sensitive detection of cellular environmental changes. By monitoring the lasing peak wavelength shift in response to the intracellular refractive index change, our NW laser probe shows a sensitivity of 55 nm per RIU (refractive index units) and a figure of merit of approximately 98.

References

Aug 10, 2005·Proceedings of the National Academy of Sciences of the United States of America·Nadine Wong Shi KamHongjie Dai
Sep 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ismail HafezManfred Lindau
May 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·Xing ChenCarolyn R Bertozzi
Aug 5, 2008·Cryobiology·Richelle C PrickettLocksley E McGann
Aug 30, 2008·Nature Methods·Ute Resch-GengerThomas Nann
Aug 15, 2009·The EMBO Journal·Dagmar MohrDirk Görlich
Dec 20, 2011·Nature Nanotechnology·Ruoxue YanPeidong Yang
Jan 20, 2012·Chemical Communications : Chem Comm·Se Won BaeJong-In Hong
Jan 25, 2012·Nano Letters·Weixia ZhangChen Yang
Feb 14, 2012·Nature Nanotechnology·Chong XieBianxiao Cui
Feb 6, 2013·Nature Nanotechnology·Micha E Spira, Aviad Hai
Feb 8, 2013·Nano Letters·Gary ShambatJelena Vučković
Aug 3, 2013·Advanced Drug Delivery Reviews·Sebastian KrussMichael S Strano
Feb 1, 2014·Nature Methods·Xudong Fan, Seok-Hyun Yun
Sep 30, 2015·Nature Photonics·Matjaž Humar, Seok Hyun Yun
Dec 23, 2015·Chemical Reviews·Anqi Zhang, Charles M Lieber
Nov 20, 2016·Physical Review Letters·Sangyeon ChoSeok Hyun Yun
Dec 29, 2016·Science Advances·John F ZimmermanBozhi Tian
Feb 10, 2017·Proceedings of the National Academy of Sciences of the United States of America·Sebastian KrussMichael S Strano
Jun 9, 2017·Nature Communications·Ekaterina I GalanzhaVladimir P Zharov
Jul 8, 2017·Lab on a Chip·Matjaž HumarSeok Hyun Yun
Oct 20, 2018·Optica·Matjaž HumarSeok Hyun Yun

❮ Previous
Next ❯

Citations

Jan 21, 2020·Advanced Materials·Zhaoshuai GaoHong-Yuan Chen
Nov 18, 2018·Nature Communications·Alasdair H FikourasMalte C Gather
Mar 21, 2020·Light, Science & Applications·Qingyang BaoLimin Tong
Feb 26, 2019·Biointerphases·Joshua D Morris, Christine K Payne
Feb 26, 2019·Biomedical Optics Express·Yu-Cheng ChenXudong Fan
Jan 14, 2021·Nanoscale·Zhiyi YuanYu-Cheng Chen
Jan 27, 2021·Light, Science & Applications·Shui-Jing TangSeok-Hyun Yun
Feb 28, 2021·Light, Science & Applications·Nikita ToropovFrank Vollmer
Mar 17, 2021·Light, Science & Applications·Qingyang BaoLimin Tong
Jun 11, 2021·Light, Science & Applications·Ting PanBaojun Li

❮ Previous
Next ❯

Methods Mentioned

BETA
scanning electron microscopy
confocal microscopy

Software Mentioned

Comsol simulation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.