Nanozyme-Catalyzed Cascade Reactions for Mitochondria-Mimicking Oxidative Phosphorylation

Angewandte Chemie
Youqian XuJunbai Li

Abstract

Multiple-enzyme-involving cascade reactions that yield bioenergy are necessary in natural oxidative phosphorylation. However, in vitro applications are hampered by the sensitivity of catalytic activity to environmental adaptation. Herein, we explore nanozyme-catalyzed cascade reactions in an assembled hybrid architecture for mitochondria-mimicking oxidative phosphorylation. Hollow silica microspheres containing trapped gold nanoparticles were synthesized to promote two enzyme-like catalytic reactions that transform glucose into gluconic acid in the presence of oxygen. The resulting transmembrane proton gradient drives natural ATP synthase reconstituted on the surface to convert ADP and inorganic phosphate into ATP. The assembled architecture possesses high activity for oxidative phosphorylation, comparable to that of natural mitochondria. This study provides a new natural-artificial hybrid prototype for exploring bioenergy supply systems and holds great promise for ATP-powered bioapplications.

References

Feb 24, 2001·Nature·J W SzostakP L Luisi
Oct 24, 2002·Archives of Biochemistry and Biophysics·Andrea Hazard, Carlo Montemagno
Jul 12, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Barry Drew, Christiaan Leeuwenburgh
Feb 14, 2004·Science·Steen RasmussenMark A Bedau
Nov 4, 2004·Angewandte Chemie·Massimiliano ComottiMichele Rossi
Dec 21, 2004·Biochemical and Biophysical Research Communications·Anna Maria PorcelliMichela Rugolo
Mar 15, 2005·Biomagnetic Research and Technology·Gilles K KouassiGregory McCarty
Dec 15, 2005·Nano Letters·Hyo-Jick Choi, Carlo D Montemagno
Mar 16, 2007·Assay and Drug Development Technologies·Frank Fan, Keith V Wood
Jun 6, 2008·Nature·Sheref S MansyJack W Szostak
Jul 26, 2008·Nature Nanotechnology·Lizeng GaoXiyun Yan
Jan 9, 2009·Angewandte Chemie·Atul AsatiJ Manuel Perez
Oct 12, 2010·Science·Nicholas A Kotov
Jul 20, 2011·Angewandte Chemie·Ravinash Krishna KumarStephen Mann
Aug 22, 2013·Biomacromolecules·Jian-Hu LiSheng Zhang
Jan 21, 2014·Accounts of Chemical Research·Youhui LinXiaogang Qu
Apr 3, 2014·Advanced Materials·Youhui LinXiaogang Qu
Nov 22, 2014·Nature Communications·Amit A VernekarGovindasamy Mugesh
Sep 4, 2015·Advanced Materials·Masakazu Aono, Katsuhiko Ariga
Sep 30, 2015·Nature Communications·Kensuke KuriharaTadashi Sugawara
Nov 20, 2015·Chemical Reviews·Yingfeng TuDaniela A Wilson
Feb 10, 2016·Trends in Biochemical Sciences·Sara CogliatiLuca Scorrano
Mar 19, 2016·Angewandte Chemie·Óscar Gutiérrez-SanzMarisela Vélez
Jun 3, 2016·Chemical Society Reviews·Ipsita NathFrancis Verpoort
Jan 18, 2017·Accounts of Chemical Research·Bastiaan C Buddingh', Jan C M van Hest
Mar 11, 2017·Nature Chemistry·Yan QiaoStephen Mann
Jul 7, 2017·Nature Protocols·Giampaolo MorcianoPaolo Pinton
Aug 24, 2017·Angewandte Chemie·Youqian XuJunbai Li
Nov 28, 2017·Bioconjugate Chemistry·Yibo ZhouJuewen Liu
Nov 29, 2017·Biochimica Et Biophysica Acta. Biomembranes·Sardar E GasanovRuben K Dagda
Dec 3, 2017·Nature Communications·Lorenz M R KeilChristof B Mast
Feb 10, 2018·Angewandte Chemie·Sourav GhoshGovindasamy Mugesh

❮ Previous
Next ❯

Citations

Oct 31, 2020·Advanced Materials·Lang MaLi Qiu
Apr 25, 2021·Advanced Materials·Weiqing XuChengzhou Zhu
Jun 18, 2021·Nano-micro Letters·Javier Lou-FrancoCuong Cao
Dec 31, 2020·ACS Applied Materials & Interfaces·Huiyao ShiLianqing Liu
Aug 23, 2019·Analytical Chemistry·Lei JiaoChengzhou Zhu
Aug 19, 2021·Nature Communications·Lado OtrinTanja Vidaković-Koch
Feb 27, 2020·Journal of the American Chemical Society·Yanjuan SangXiaogang Qu
Sep 26, 2019·ACS Nano·Ruijuan YanDong Ming
Oct 27, 2021·Macromolecular Rapid Communications·Jianan HuangJunyou Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved