Naphthalene cytotoxicity of differentiating Clara cells in neonatal mice

Toxicology and Applied Pharmacology
M V FanucchiC G Plopper

Abstract

Selective Clara cell injury produced by many bioactivated lung toxicants is thought to result from high levels of activating enzymes found in differentiated Clara cells. A recent study found an elevated susceptibility to the Clara cell toxicant 4-ipomeanol in neonatal rabbits when Clara cell P450 activity is low. To determine whether differentiating Clara cells in another species (mouse) are more susceptible to injury by a different bioactivated Clara cell toxicant (naphthalene), adult, 14-day postnatal (DPN) and 7DPN male mice were given a single intraperitoneal dose (25, 50, or 100 mg/kg) of naphthalene and killed 24 hr later. Epithelial damage, as assessed by quantitative histopathology, included cellular swelling, vacuolization, and exfoliation. In 7DPN mice, bronchiolar epithelium was severely injured at the lowest dose of naphthalene tested, 25 mg/kg. Bronchiolar epithelium in 14DPN mice was moderately injured at 25 mg/kg; injury severity was greatest at 50 and 100 mg/kg. Minimal bronchiolar epithelial injury occurred in adult mice at 50 mg/kg and moderate injury at 100 mg/kg. In proximal bronchi, epithelium of 7DPN mice showed signs of injury only at 100 mg/kg. Bronchial epithelium of adult mice was not injured at any do...Continue Reading

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Citations

Dec 22, 2007·Journal of Toxicology and Environmental Health. Part a·Thomas F Bateson, Joel Schwartz
Feb 21, 2006·Clinical and Experimental Pharmacology & Physiology·Kent E Pinkerton, Jesse P Joad
Aug 10, 2010·American Journal of Respiratory Cell and Molecular Biology·Vedang A LondheParviz Minoo
Jun 15, 2000·Environmental Health Perspectives·K E Pinkerton, J P Joad
May 7, 2010·Environmental Health Perspectives·Mark D Miller, Melanie A Marty
Feb 3, 2004·Environmental Health Perspectives·George DastonTara J McLaughlin
Jan 30, 2013·Journal of Comparative Pathology·H M MartineauD J Griffiths
Aug 9, 2015·World Journal of Pediatrics : WJP·Song TangGregory D Mayer
Apr 6, 2012·Paediatric Respiratory Reviews·Peter D Sly, Karen Schüepp
Apr 6, 2012·Paediatric Respiratory Reviews·Karen Schüepp, Peter D Sly
Nov 3, 2004·Toxicology and Applied Pharmacology·Michelle V FanucchiCharles G Plopper
Apr 3, 2008·Birth Defects Research. Part C, Embryo Today : Reviews·Lei Wang, Kent E Pinkerton
Apr 26, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sarah A CarrattLaura S Van Winkle
Apr 15, 2004·The Journal of Pharmacology and Experimental Therapeutics·Bridget BolandAlan Buckpitt
Feb 8, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kimberly C DayMichelle V Fanucchi
Jul 17, 2010·Journal of Applied Physiology·DongYoub LeeJackie K W Chan
Mar 16, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F Broeckaert, A Bernard
Oct 24, 2000·Toxicology and Applied Pharmacology·M V FanucchiC G Plopper

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