Naphthalocyanine as a New Photothermal Actuator for Lipid-Based Drug Delivery Systems

The Journal of Physical Chemistry. B
Joanne D DuBen J Boyd

Abstract

One approach to address the substantial global burden of ocular diseases such as aged related macular degeneration is using light-activated drug delivery to obviate the need for highly invasive and frequent, costly intravitreal injections. To enable such systems, new light responsive materials are required. This communication reports the use of silicon 2,3-naphthalocyanine bis(trihexylsilyloxide) (SiNC), a small molecule photosensitizer, as a new actuator for triggering light responsive lipid-based drug delivery systems. Small-angle X-ray scattering was used to confirm that the addition of SiNC imparted light sensitivity to the lipid systems, resulting in a complete phase transition within 20 s of near-infrared irradiation. The phase transition was also reversible, suggesting the potential for on-demand drug delivery. When compared to the phase transitions induced using alternative light responsive actuators, gold nanorods and graphene, there were some differences in phase behavior. Namely, the phytantriol with SiNC system transitioned directly to the inverse micellar phase, skipping the intermediate inverse hexagonal structure. The photodynamic properties and efficiency in controlling the release of drug suggest that SiNC-actu...Continue Reading

References

Jun 5, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Yao-Da DongBen J Boyd
Apr 3, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Wye-Khay FongBen J Boyd
Apr 7, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Yao-Da DongBen J Boyd
Feb 4, 2012·Expert Opinion on Pharmacotherapy·Matthew Ohr, Peter K Kaiser
Sep 14, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Wye-Khay FongBen J Boyd
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Apr 5, 2014·Nature Communications·Kevin A CarterJonathan F Lovell
Mar 25, 2015·Journal of Ophthalmology·Makoto IshikawaTakeshi Yoshitomi
May 9, 2015·Physical Chemistry Chemical Physics : PCCP·Joanne D DuBen J Boyd
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Oct 6, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vianney DelplaceMolly Shoichet
May 20, 2016·Drug Delivery and Translational Research·Joanne D DuBen J Boyd
Jul 22, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Yumiao Zhang, Jonathan F Lovell
Aug 28, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatu LajunenArto Urtti
Sep 14, 2016·Journal of Colloid and Interface Science·Wye-Khay FongBen J Boyd
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Citations

Sep 12, 2018·Beilstein Journal of Organic Chemistry·Lei ZouXiang Ma
Oct 5, 2019·Pharmaceutical Nanotechnology·Linda HongBen J Boyd
Aug 31, 2018·The Journal of Physical Chemistry. B·Marcos G RussoGriselda E Narda

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