NaPi-IIa interacting partners and their (un)known functional roles

Pflügers Archiv : European journal of physiology
Nati Hernando

Abstract

The sorting and stabilization of proteins at specific subcellular domains depend upon the formation of networks build up by specific protein-protein interactions. In addition, protein networks also ensure the specificity of many regulatory processes by bringing together regulatory molecules with their targets. Whereas the success on the identification of protein-protein interactions is (up to a point) technology-driven, the assignment of functional roles to specific partners remains a major challenge. This review summarizes the work that led to the identification of partners of the Na+/phosphate cotransporter NaPi-IIa as well as the effects of the interactions in the expression and/or regulation of the cotransporter.

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Citations

Jun 7, 2019·Nature Reviews. Nephrology·Moshe LeviHeini Murer
Dec 14, 2018·Pflügers Archiv : European journal of physiology·Eleanor Lederer, Carsten A Wagner
Dec 21, 2018·Pflügers Archiv : European journal of physiology·Heini MurerAndreas Werner
May 1, 2020·Physiological Reviews·Nati HernandoEleanor Lederer
Jan 28, 2021·International Journal of Molecular Sciences·Tatyana Mamonova, Peter A Friedman

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Methods Mentioned

BETA
two-hybrid
Y2H
GTPase
transfection
myristoylation

Software Mentioned

Pist
Clamp

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