PMID: 6407271Jan 1, 1983Paper

Naproxen in the treatment of OC-resistant primary dysmenorrhea. A double-blind cross-over study

Acta Obstetricia Et Gynecologica Scandinavica. Supplement
J JacobsonB Nilsson

Abstract

The efficacy of oral contraceptives (OC) in the treatment of primary dysmenorrhea in controlled studies varies from 50 to 80%. The addition of a prostaglandin synthetase inhibitor, naproxen, was found to afford pain relief to a further 70% of women with OC-resistant dysmenorrhea in a double-blind cross-over study comprising 39 patients. This effect was shown to be statistically significant at p = 0.0005. Our recommendation is that low-dose OCs should be the first choice as contraceptive agents for women with dysmenorrhea and that a prostaglandin synthetase inhibitor should be given when OCs are ineffective.

Citations

Nov 5, 2002·Fertility and Sterility·Joseph C GamboneUNKNOWN Chronic Pelvic Pain/Endometriosis Working Group
Aug 1, 2015·The Cochrane Database of Systematic Reviews·Jane MarjoribanksMichelle Proctor
Aug 6, 1998·British Journal of Obstetrics and Gynaecology·W Y Zhang, A Li Wan Po

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