Narcolepsy and Psychiatric Disorders: Comorbidities or Shared Pathophysiology?

Medical Sciences : Open Access Journal
Anne Marie Morse, Kothare Sanjeev

Abstract

Narcolepsy and psychiatric disorders have a significant but unrecognized relationship, which is an area of evolving interest, but unfortunately, the association is poorly understood. It is not uncommon for the two to occur co-morbidly. However, narcolepsy is frequently misdiagnosed initially as a psychiatric condition, contributing to the protracted time to accurate diagnosis and treatment. Narcolepsy is a disabling neurodegenerative condition that carries a high risk for development of social and occupational dysfunction. Deterioration in function may lead to the secondary development of psychiatric symptoms. Inversely, the development of psychiatric symptoms can lead to the deterioration in function and quality of life. The overlap in pharmaceutical intervention may further enhance the difficulty to distinguish between diagnoses. Comprehensive care for patients with narcolepsy should include surveillance for psychiatric illness and appropriate treatment when necessary. Further research is necessary to better understand the underlying pathophysiology between psychiatric disease and narcolepsy.

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Citations

Jul 12, 2020·Current Neurology and Neuroscience Reports·Arpita ParmarIndra Narang
Dec 1, 2019·Medical Sciences : Open Access Journal·Anne Marie Morse
Jun 10, 2020·Current Psychiatry Reports·Ahmed S BaHammamSeithikuruppu R Pandi-Perumal
Sep 9, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·David G IngramStacey L Simon
Mar 2, 2019·Sleep & Breathing = Schlaf & Atmung·Aljohara S AlmeneessierAhmed S BaHammam
Jul 8, 2019·Sleep & Breathing = Schlaf & Atmung·Haithm AlasimAhmed S BaHammam

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