PMID: 6539848May 7, 1984Paper

Narcolepsy: cholinergic receptor changes in an animal model

Life Sciences
R E BoehmeR D Ciaranello

Abstract

An inbred colony of narcoleptic doberman pinschers has been analyzed for muscarinic receptor levels in 19 discrete brain regions. In comparison to age-matched controls, receptors were generally elevated in the brainstem and reduced in forebrain areas. No changes in receptor binding affinity were detected. The increased receptor levels found in the brainstem suggest that cholinoceptive neurons in this region are hypersensitive and may be involved in the initiation of cataplexy and other aspects of the narcolepsy syndrome.

References

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Citations

Feb 16, 1990·Neuroscience Letters·M Pompeiano, G Tononi
May 1, 1997·Progress in Neurobiology·S Nishino, E Mignot
Oct 29, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yves DauvilliersJacques Montplaisir
Aug 9, 1990·The New England Journal of Medicine·M S Aldrich
Jan 2, 2016·Progress in Neurobiology·Sarah Wurts BlackThomas S Kilduff
Aug 6, 2009·Progress in Neurobiology·Mortimer Mamelak
May 2, 2007·Sleep Medicine·Seiji Nishino
May 16, 2014·Immunologic Research·Emmanuel J M Mignot
Nov 26, 2015·The Psychiatric Clinics of North America·Michael D Schwartz, Thomas S Kilduff
Jan 18, 2003·Sleep Medicine Reviews·Seiji NishinoEmmanuel Mignot
Jan 1, 1988·The International Journal of Neuroscience·R SandykE Labadie
Jan 27, 1987·Brain Research·S S BowersoxR D Ciaranello
Jun 19, 2021·Progress in Neurobiology·Yi-Qun WangZhi-Li Huang

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