PMID: 6105624Jul 1, 1980Paper

Narcotic analgesics and stereotyped behaviour in mice

Naunyn-Schmiedeberg's Archives of Pharmacology
R Langwiński, J Niedzielski

Abstract

In this paper we have studied the effects of morphine, codeine, fentanyl, pentazocine, etorphine and fluphenazine (all drugs injected i.p.) on stereotyped behaviour induced by methylphenidate 60 mg/kg i.p., as well as induced by apomorphine 5 mg/kg s.c. in mice. It was found that all used analgesics and fluphenazine dose--dependently inhibited the intensity of methylphenidate--induced gnawing in mice. This effect of analgesics, but not that of fluphenazine was antagonized by naloxone (0.8 mg/kg i.p.) and nalorphine (10 mg/kg i.p.). Climbing behaviour induced by apomorphine was not reduced by narcotic analgesics, but fluphenazine inhibited this effect dose--dependently. These findings give the behavioural support that analgesics applied have antidopaminergic activity in mice.

References

Mar 1, 1977·The Journal of Pharmacy and Pharmacology·J MajA Rawlów
Nov 25, 1977·Pflügers Archiv : European journal of physiology·W SchneiderK Thurau
Oct 1, 1978·The Journal of Pharmacy and Pharmacology·J A Garcia-SevillaA Carlsson
Jan 1, 1972·Acta Pharmacologica Et Toxicologica·V Pedersen, A V Christensen

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Citations

Feb 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·P ProtaisJ C Schwartz
Aug 1, 1982·Neuropharmacology·O Aroyewun, G A Barr
Sep 1, 1987·Journal of Affective Disorders·B A van der Kolk
Jan 1, 1986·Progress in Neuro-psychopharmacology & Biological Psychiatry·P N TariotR M Cohen
Jul 1, 1981·Brain Research Bulletin·I S Zagon, P J McLaughlin

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