PMID: 9654Jun 23, 1976

Narcotic blockade, length of addiction and persistence of etonitazene consumption in rats

Psychopharmacology
R E MeyerJ Cochin

Abstract

Rats were given daily trials to determine relative preference for an opiate (etonitazene, ETZ) or for water. Animals with a greater history of previous drug exposure developed ETZ preferences more rapidly than did relatively drug-naive animals. Pretreatment with adequate blocking doses of naloxone reduced drug intake to near zero in most subjects. However, animals with the greatest history of prior addiction continued to drink large quantities of ETZ, despite pretreatment with relatively large doses of naloxone. These results can be explained by assuming that stimuli associated with the reinforcing properties of the opioid solution become strong conditioned reinforcers, capable of maintaining responding for long periods of time despite blockade of the reinforcement properties of the drug.

References

Mar 1, 1976·Archives of General Psychiatry·R E MeyerH B McNamee
Jan 1, 1974·Archives of General Psychiatry·H KleberD Sweeney
Jan 1, 1970·Psychopharmacologia·I P Stolerman, R Kumar
Sep 6, 1974·Science·J GARCIAK W Rusiniak

Citations

Dec 1, 1977·Pharmacology, Biochemistry, and Behavior·R M WursterJ V Brady
Apr 1, 1979·Pharmacology, Biochemistry, and Behavior·T U JärbeM D Swedberg
Oct 1, 1989·Pharmacology, Biochemistry, and Behavior·K R Carlson
Jan 1, 1984·The American Journal of Drug and Alcohol Abuse·E G SingletonG E Bigelow
Jan 1, 1979·The American Journal of Drug and Alcohol Abuse·J GrabowskiS Steinberg-Donato
Jul 8, 1982·Brain Research·R F MuchaP Bucenieks

Related Concepts

Opioids
Metazoa
Benzimidazoles
Diethylamines
Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer
Psychological Reinforcement
Substance-Related Disorders
Rats, Laboratory

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