Nardostachys jatamansi protects against cerulein-induced acute pancreatitis

Pancreas
Gi-Sang BaeSung-Joo Park

Abstract

Nardostachys jatamansi belonging to the family Valerianaceae has been used as a remedy for stomach and skin ailments in Korea. The effect of N. jatamansi on acute pancreatitis (AP) has not been defined. Therefore, we investigated the effect of N. jatamansi on cerulein-induced AP. In the pretreatment group, N. jatamansi was administered orally to mice at 10 and 20 mg/kg for 5 days, and the mice were intraperitoneally injected with the stable cholecystokinin analogue cerulein hourly for 6 hours. In the posttreatment group, cerulein was injected hourly for 6 hours, and N. jatamansi was administered at the indicated time (1, 3, and 5 hours after the first cerulein injection) and dose (10 and 20 mg/kg) during the cerulein injection. Blood samples were taken 6 hours later to determine the serum amylase, the lipase, and the cytokine levels. The pancreas and the lung were rapidly removed for morphologic examination, myeloperoxidase assay, and real-time reverse transcription polymerase chain reaction. Nardostachys jatamansi treatment attenuated the AP, as shown by the histological examination results of the pancreas and the lung, reductions in pancreatic edema, neutrophil infiltration, serum amylase and lipase levels, serum cytokine lev...Continue Reading

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Citations

Aug 28, 2010·Journal of Natural Medicines·Gi-Sang BaeSung-Joo Park
Dec 12, 2013·Pancreas·Sun Bok ChoiSung-Joo Park
Jul 9, 2010·World Journal of Gastroenterology : WJG·Mi-Young SongByung-Hyun Park
Aug 7, 2013·Digestive Diseases and Sciences·Gi-Sang BaeSung-Joo Park
Jul 17, 2015·Phytotherapy Research : PTR·Min-Jun KimSung-Joo Park
Sep 27, 2015·European Journal of Pharmacology·Myoung-Jin KimSung-Joo Park
May 6, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Gi-Sang BaeSung-Joo Park
Sep 24, 2011·International Immunopharmacology·Seung-Won YunSung-Joo Park
Mar 16, 2017·Phytotherapy Research : PTR·Pratibha AnchiChandraiah Godugu
Nov 28, 2012·Experimental and Therapeutic Medicine·Gi-Sang BaeSung-Joo Park
Dec 20, 2019·Pancreas·Myoung-Jin KimSung-Joo Park
Dec 24, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity

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