Naringenin alleviates cognition deficits in high-fat diet-fed SAMP8 mice.

Journal of Food Biochemistry
Tao ZhouYing Gao

Abstract

Naringenin is a natural dihydro flavonoid that is abundant in grapefruit. Previous studies suggested the cognition protective effect of naringenin in various cognitive deficits models, such as type 2 diabetic rat model and chemicals (e.g., lipopolysaccharide, scopolamine) treated rodents. However, the effects of naringenin on aging animals and the potential mechanisms are still unclear. In this study, we investigated the influence of naringenin administration on learning deficits in aging mice. High-fat diet-fed SAMP8 mice were employed as an age-related model of Alzheimer's disease. Dietary administration of 0.2% naringenin for 12 weeks significantly improved the spatial learning and memory performance of the high-fat diet-fed SAMP8 mice in both Barnes Maze test and Morris Water Maze test. Further mechanism research indicated that naringenin reduced Aβ production, tau-hyperphosphorylation, oxidative stress, and neuroinflammation in the brain. This research provides further evidence for the treatment effect of naringenin on Alzheimer's disease. PRACTICAL APPLICATIONS: Naringenin, also known as 4',5,7-thrihydroxyflflavanone, is a natural dihydro flavonoid that is abundant in grapefruit and other citrus fruits. The current study ...Continue Reading

References

Mar 21, 2013·The International Journal of Neuroscience·Atish PrakashAnil Kumar
Aug 8, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Thomas ClairembaultPascal Derkinderen
Nov 6, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Gunnar K GourasOskar Hansson
Jan 2, 2016·Pharmacological Reports : PR·Justyna GodyńBarbara Malawska
Apr 20, 2016·International Journal of Molecular Sciences·Mohammed Kawser HossainSsang-Goo Cho
Nov 25, 2016·Journal of Cellular Biochemistry·Mauro B FrançaElis C A Eleutherio
Dec 29, 2016·Oncotarget·Marília F ManchopeWaldiceu A Verri
Jan 15, 2017·Journal of Neuroinflammation·Charbel MoussaR Scott Turner
Sep 12, 2017·The Proceedings of the Nutrition Society·Louise DyeClare Lawton
Oct 29, 2017·Redox Biology·C CheignonF Collin
Feb 10, 2018·Translational Neurodegeneration·Xiaoguang DuMeiyu Geng
Feb 13, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jianping JiaSerge Gauthier
Feb 17, 2018·Nature Reviews. Neurology·Victor L VillemagneChristopher C Rowe
Mar 9, 2018·European Journal of Pharmacology·Mohammad-Reza Khajevand-KhazaeiMehrdad Roghani
Jun 30, 2018·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Jeffrey CummingsKate Zhong
Jul 10, 2018·The Journal of Nutritional Biochemistry·Miao-Miao ZhouYu-Ming Wang
Apr 8, 2019·Clinical Biochemistry·Tomris Ozben, Serkan Ozben
Aug 4, 2019·Environmental Toxicology and Pharmacology·Adwaid Manu Krishna ChandranB S Satish Rao

❮ Previous
Next ❯

Citations

Mar 9, 2021·Frontiers in Neuroscience·Matthew G PontifexDavid Vauzour

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Aging & Diabetes

This feed focuses on the role of the aging process on developing diabetes.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.