Naringenin alleviates myocardial ischemia reperfusion injury by enhancing the myocardial miR-126-PI3K/AKT axis in streptozotocin-induced diabetic rats.

Experimental and Therapeutic Medicine
Shang-Hai LiMing-Rui Wang

Abstract

Ischemic heart disease (IHD) is a leading cause of death in patients with type 1 diabetes. The key to treating IHD is to restore blood supply to the ischemic myocardium, which inevitably causes myocardial ischemia reperfusion (MI/R) injury. Although naringenin (Nar) prevents MI/R injury, the role of Nar in diabetic MI/R (D-MI/R) injury remains to be elucidated. The PI3K/AKT signaling pathway and microRNA (miR)-126 have previously been shown to serve anti-MI/R injury roles. The present study aimed to investigate the protection of Nar against D-MI/R injury and the role of the miR-126-PI3K/AKT axis. Diabetic rats were treated distilled water or Nar (25 or 50 mg/kg, orally) for 30 days and then exposed to MI/R. The present results revealed that Nar alleviated MI/R injury in streptozotocin (STZ)-induced diabetic rats, as shown below: the reduction myocardial enzymes levels was measured using spectrophotometry, the increase of cardiac viability was detected by MTT assay, the inhibition of myocardial oxidative stress was measured using spectrophotometry and the enhancement of cardiac function were recorded using a hemodynamic monitoring system. Furthermore, Nar upregulated the myocardial miR-126-PI3K/AKT axis in D-MI/R rats. These res...Continue Reading

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Aug 18, 2004·Nature Neuroscience·Patricia ViardAnnette C Dolphin
May 17, 2006·Journal of Cardiovascular Pharmacology and Therapeutics·Margaret A NordlieRobert A Kloner
Sep 15, 2007·The New England Journal of Medicine·Derek M Yellon, Derek J Hausenloy
Dec 25, 2007·European Journal of Pharmacology·Xiuzhen HanHongxiang Lou
Jul 26, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xiuzhen HanHongxiang Lou
Jul 30, 2009·Pharmacology & Therapeutics·Adarsh KumarVarun Mohan
Apr 29, 2010·Current Diabetes Reports·Trevor J Orchard, Tina Costacou
Jul 14, 2010·Neurobiology of Learning and Memory·Pravinkumar BhutadaDharmendra Mundhada
Mar 31, 2012·Cardiology Research and Practice·Hannah J WhittingtonDerek J Hausenloy
Apr 20, 2014·Current Cardiology Reports·Thomas F Whayne
Aug 28, 2014·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Hong YaoXiuzhen Han
Sep 20, 2015·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Hongyu ZhaoZhigang Zhang
Oct 21, 2015·Pharmacological Reports : PR·Yassine ChtourouHamadi Fetoui
Jan 1, 2016·Journal of Molecular and Cellular Cardiology·Anne LejayJames W Scholey
May 20, 2016·Cardiovascular Research·Victoria R PellThomas Krieg
Jun 9, 2016·The Journal of Endocrinology·Qiong YouJingfu Chen
Feb 12, 2017·Frontiers in Physiology·Urszula KołodziejAnna Zalewska
Apr 26, 2017·Current Pharmaceutical Design·Elham Pishavar, Javad Behravan
Oct 19, 2017·Biomarkers in Medicine·Christoph SinningPeter Clemmensen
May 21, 2018·Biochemical and Biophysical Research Communications·Jie ZhangQingsong Jiang
Sep 1, 2018·Diabetes & Metabolic Syndrome·Anneh Mohammad GharraviParinaz Hajiasgarli
Oct 17, 2018·Mini Reviews in Medicinal Chemistry·Seyithan TaysiMustafa Demir
Oct 31, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Weronika WojnarIlona Kaczmarczyk-Sedlak
Dec 21, 2018·Arquivos brasileiros de cardiologia·Roya NaderiRana Ghaznavi
Jan 13, 2019·Pharmaceuticals·Bahare SalehiJavad Sharifi-Rad
Apr 3, 2019·Atherosclerosis·Abbas Shapouri MoghaddamAmir Abbas Momtazi-Borojeni
May 8, 2019·Biochemical and Biophysical Research Communications·Hai-Yun GaiDong Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Medicinal Chemistry
María Angélica RivoiraNori Tolosa de Talamoni
Current Opinion in Allergy and Clinical Immunology
Kari R Brown, Jonathan A Bernstein
Gan to kagaku ryoho. Cancer & chemotherapy
S Nagase, M Takahashi
© 2021 Meta ULC. All rights reserved