Naringenin inhibits dendritic cell maturation and has therapeutic effects in a murine model of collagen-induced arthritis

The Journal of Nutritional Biochemistry
Yi-Rong LiChi-Chen Lin

Abstract

The aim of this study was to investigate the effect of naringenin (5,7,4'-trihydroxyflavanone), a citrus flavonoid, on dendritic cell (DC) maturation, as well as its potential as a therapeutic agent in a murine model of collagen-induced arthritis (CIA). Naringenin effectively inhibited lipopolysaccharide (LPS)-induced DC maturation as shown by reductions in the production of proinflammatory cytokines/chemokines, the expression of costimulatory molecules and the Ag-specific T cell priming ability of DCs when given at noncytotoxic doses. In addition, the decrease of LPS-induced MAPK and NF-κB signaling activation may contribute to the inhibitory activity of naringenin. In mice with CIA, the oral administration of naringenin ameliorated the severity of arthritis, reduced the levels of anticollagen Type II (CII) IgG and limited the proliferation of T cells, observed as a lower frequency of Th1 and Th17 cells in the spleen after restimulation with CII. In conclusion, this study shows for the first time that naringenin can manipulate the immunostimulatory properties of DCs and thus represents a potential therapeutic for the treatment of rheumatoid arthritis in humans.

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Citations

Oct 28, 2016·Cell Stress & Chaperones·Mouna MaatoukLeila Chekir-Ghedira
Nov 23, 2016·Critical Reviews in Food Science and Nutrition·Samuel D HughesNagaraja Haleagrahara
Dec 25, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luoyang WangWei Liang
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May 13, 2018·International Journal of Molecular Sciences·Sen-Wei TsaiChi-Chien Lin
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Mar 19, 2021·Phytotherapy Research : PTR·Syed Afroz AliAshok Kumar Datusalia
Jun 4, 2019·Journal of Agricultural and Food Chemistry·Cheng Hsuan ChuangChi-Chien Lin

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