Naringenin inhibits human osteoclastogenesis and osteoclastic bone resorption

Journal of Periodontal Research
V D LaD Grenier

Abstract

Naringenin, a naturally occurring flavonoid, possesses a wide range of pharmacological properties. The purpose of this study was to investigate the effect of naringenin on human osteoclastogenesis and osteoclastic bone resorption. Naringenin was tested in a human osteoclastogenesis model using primary osteoclast precursor cells activated by receptor activator of nuclear factor-kappaB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) for 6 days. Osteoclastogenesis was assessed by determining the number of tartrate-resistant acid phosphatase (TRAP)-stained multinuclear cells, while the secretion of factors involved in osteoclastogenesis was assessed using enzyme-linked immunosorbent assays. The effect of naringenin on bone resorption was investigated using an OsteoAssay human bone plate coupled with an immunoassay to evaluate the release of helical peptide 620-633 from the alpha1 chain of type I collagen. Naringenin was non-toxic at the highest concentration used (50 microg/ml). Naringenin (10, 25 and 50 microg/ml) significantly inhibited osteoclastogenesis (by 29 +/- 5, 57 +/- 8 and 96 +/- 1%, respectively). Naringenin also markedly inhibited the secretion of interleukin (IL)-1alpha (by 59%), IL-23 (by 87%) and mon...Continue Reading

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Citations

Mar 25, 2011·Critical Reviews in Food Science and Nutrition·R GonzálezF Sánchez de Medina
Jul 15, 2015·Journal of Natural Products·Renata M MartinezRubia Casagrande
Jun 13, 2015·Critical Reviews in Food Science and Nutrition·Leslie A Nash, Wendy E Ward
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Aug 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Seon-A JangHyunil Ha
Oct 9, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Richard KomakechYoungmin Kang

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