Naringenin prevents obesity, hepatic steatosis, and glucose intolerance in male mice independent of fibroblast growth factor 21

Endocrinology
Julia M AssiniMurray W Huff

Abstract

The molecular mechanisms and metabolic pathways whereby the citrus flavonoid, naringenin, reduces dyslipidemia and improves glucose tolerance were investigated in C57BL6/J wild-type mice and fibroblast growth factor 21 (FGF21) null (Fgf21(-/-)) mice. FGF21 regulates energy homeostasis and the metabolic adaptation to fasting. One avenue of this regulation is through induction of peroxisome proliferator-activated receptor-γ coactivator-1α (Pgc1a), a regulator of hepatic fatty acid oxidation and ketogenesis. Because naringenin is a potent activator of hepatic FA oxidation, we hypothesized that induction of FGF21 might be an integral part of naringenin's mechanism of action. Furthermore, we predicted that FGF21 deficiency would potentiate high-fat diet (HFD)-induced metabolic dysregulation and compromise metabolic protection by naringenin. The absence of FGF21 exacerbated the response to a HFD. Interestingly, naringenin supplementation to the HFD robustly prevented obesity in both genotypes. Gene expression analysis suggested that naringenin was not primarily targeting fatty acid metabolism in white adipose tissue. Naringenin corrected hepatic triglyceride concentrations and normalized hepatic expression of Pgc1a, Cpt1a, and Srebf1...Continue Reading

References

Sep 13, 2002·Journal of the American College of Cardiology·Fahim AbbasiGerald M Reaven
Jun 3, 2004·The Journal of Clinical Investigation·Soren NielsenMichael D Jensen
May 20, 2005·The Journal of Clinical Investigation·Alexei KharitonenkovArmen B Shanafelt
Feb 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Scott M Grundy
Apr 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yasushi OgawaMakoto Kuro-o
Jul 11, 2007·TheScientificWorldJournal·Per Lindström
Dec 8, 2007·Journal of Cellular Physiology·Alexei KharitonenkovArmen B Shanafelt
Mar 28, 2008·Current Diabetes Reports·Martin AdielsJan Borén
Jun 21, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Martin AdielsJan Borén
Aug 9, 2008·Endocrinology·Tamer CoskunAlexei Kharitonenkov
Feb 5, 2009·Current Diabetes Reports·Dario A GutierrezAlyssa H Hasty
Jun 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Matthew J PotthoffShawn C Burgess
Aug 12, 2009·Gastroenterology·Charis L JohnsonChristopher L Pin
Aug 18, 2009·Current Opinion in Pharmacology·Alexei Kharitonenkov
Aug 27, 2009·American Journal of Physiology. Endocrinology and Metabolism·Jing XuMurielle M Véniant
Oct 13, 2009·Endocrinology·Michael K BadmanEleftheria Maratos-Flier
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ken-ichi TomiyamaYo-ichi Nabeshima
Jan 30, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Erin E MulvihillMurray W Huff
Aug 7, 2010·Journal of Applied Physiology·Patrick V GrantonDavid W Holdsworth
Jan 26, 2011·Annals of the New York Academy of Sciences·Clifton A BaileMary Anne Della-Fera
Jun 30, 2011·Endocrinology·Ffolliott M FisherEleftheria Maratos-Flier
Feb 4, 2012·Genes & Development·Ffolliott M FisherBruce M Spiegelman

❮ Previous
Next ❯

Citations

Jul 2, 2016·The Journal of Surgical Research·Yan LiuAibao Gao
Mar 16, 2016·Journal of Physiology and Biochemistry·Jarinyaporn NaowabootPatchareewan Pannangpetch
Jun 28, 2015·The Journal of Endocrinology·Kook Hwan Kim, Myung-Shik Lee
Apr 20, 2016·International Journal of Molecular Sciences·Mohammed Kawser HossainSsang-Goo Cho
Jun 17, 2016·Phytotherapy Research : PTR·Masoumeh Akhlaghi
Jul 26, 2016·Frontiers in Endocrinology·Patrick Joseph AntonellisAndrew Charles Adams
May 6, 2016·Annual Review of Nutrition·Erin E MulvihillMurray W Huff
Oct 1, 2016·Molecular Metabolism·Miguel Angel Sánchez-GarridoAlexei Kharitonenkov
Oct 1, 2016·Molecular Metabolism·Christopher D MorrisonHans-Rudolf Berthoud
Jan 12, 2017·Cell Metabolism·Julien Chilloux, Marc-Emmanuel Dumas
Mar 21, 2017·Molecular Nutrition & Food Research·Rosalia Rodriguez-RodriguezRosa M Lamuela-Raventos
Jun 9, 2017·Hormone Molecular Biology and Clinical Investigation·Mathias Z Strowski
Aug 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·A Berenice Aguilar-Guadarrama, María Yolanda Rios
Feb 15, 2018·Virology Journal·Ana Carolina Gomes JardimMark Harris
Mar 16, 2019·Biomolecules·Danja J Den Hartogh, Evangelia Tsiani
Nov 2, 2019·Journal of Medicinal Food·Navya MurugesanCandida J Rebello
Jul 31, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jun Feng LuJiang Wei Wu
Nov 24, 2016·Journal of Internal Medicine·A Kharitonenkov, R DiMarchi
May 23, 2018·Mediators of Inflammation·Lucrecia Carrera-QuintanarDaniel Ortuño-Sahagún
Oct 8, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Babalwa U JackCarmen Pheiffer
Dec 13, 2019·Journal of Agricultural and Food Chemistry·Jianhui LiuZhen-Yu Chen
Dec 22, 2020·Therapeutic Advances in Musculoskeletal Disease·Kristin E YuFrancis Y Lee
Jan 9, 2019·Trends in Pharmacological Sciences·Yongde LuoWeiqin Lu
Jan 10, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Tarique HussainYulong Yin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.