Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pathway

Neuropharmacology
Haiyan LouXiumei Zhang

Abstract

There is increasing evidence that oxidative stress is critically involved in the pathogenesis of Parkinson's disease (PD), suggesting that pharmacological targeting of the antioxidant machinery may have therapeutic value. Naringenin, a natural flavonoid compound, has been reported to possess neuroprotective effect against PD related pathology; however the mechanisms underlying its beneficial effects are poorly defined. Thus, the purpose of the present study was to investigate the potential neuroprotective role of naringenin and to delineate its mechanism of action against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in models of PD both in vitro and in vivo. Naringenin treatment resulted in an increase in nuclear factor E2-related factor 2 (Nrf2) protein levels and subsequent activation of antioxidant response element (ARE) pathway genes in SH-SY5Y cells and in mice. Exposure of SH-SY5Y cells to naringenin provided protection against 6-OHDA-induced oxidative insults that was dependent on Nrf2, since treatment with Nrf2 siRNA failed to block against 6-OHDA neurotoxicity or induce Nrf2-dependent cytoprotective genes in SH-SY5Y cells. In mice, oral administration of naringenin resulted in significant protection against 6-OHDA-...Continue Reading

References

Mar 19, 2003·Journal of Neurochemistry·Kuresh A YoudimCatherine Rice-Evans
Mar 20, 2004·Journal of Agricultural and Food Chemistry·Ho Jin HeoDong-Hoon Shin
Dec 13, 2005·Journal of Neurochemistry·Armando P SignoreJun Chen
Jul 11, 2006·The Journal of Clinical Investigation·Joseph M SavittTed M Dawson
Jan 6, 2007·Journal of Neuropathology and Experimental Neurology·Chenere P RamseyKelly L Jordan-Sciutto
Feb 28, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Heather KlintworthZhengui Xia
Aug 23, 2008·Antioxidants & Redox Signaling·Marcus J CalkinsJeffrey A Johnson
Feb 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Pei-Chun ChenJeffrey A Johnson
Feb 25, 2009·Expert Opinion on Therapeutic Targets·Antonio CuadradoJosé Pedraza-Chaverri
Mar 4, 2010·BMC Medical Genetics·Malin von OtterHenrik Zetterberg
Mar 11, 2010·Science Signaling·Gerasimos P Sykiotis, Dirk Bohmann
Mar 8, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Kevin Y ZhuKarl W K Tsim
Feb 7, 2012·Nutritional Neuroscience·Sonia Luz AlbarracinGeorge E Barreto
Apr 16, 2013·Experimental Neurobiology·Onyou Hwang

❮ Previous
Next ❯

Citations

Feb 2, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chiara CostaConcettina Fenga
Feb 26, 2016·Neuropharmacology·Felipe A Pinho-RibeiroWaldiceu A Verri
Aug 19, 2015·Free Radical Biology & Medicine·Delinda A Johnson, Jeffrey A Johnson
Nov 8, 2014·Cellular and Molecular Neurobiology·Xiaohua JinXuan Wang
Oct 31, 2014·Human Molecular Genetics·William M JohnsonShu G Chen
Nov 18, 2015·Oxidative Medicine and Cellular Longevity·Kasthuri Bai MagalingamNagaraja Haleagrahara
Nov 15, 2016·Nutritional Neuroscience·Shinki MurakamiMasato Asanuma
Jun 1, 2017·International Journal of Molecular Sciences·Kelsey E Murphy, Joshua J Park
Feb 8, 2018·Journal of Medicinal Food·Un Ju Jung, Sang Ryong Kim
Feb 8, 2018·Neurochemical Research·Marcos Roberto de OliveiraCristina Ribas Fürstenau
Jul 20, 2019·Phytotherapy Research : PTR·Alireza TavakkoliGholamreza Karimi
Jul 14, 2020·Medicinal Research Reviews·Plamena R AngelovaAndrey Y Abramov
Apr 17, 2020·Current Topics in Medicinal Chemistry·Gagandeep MaanAwanish Mishra
Aug 9, 2017·Neurochemical Research·Marcos Roberto de OliveiraCláudia Marlise Balbinotti Andrade
May 2, 2018·World Journal of Gastroenterology : WJG·Erika Hernández-Aquino, Pablo Muriel
Jun 14, 2018·Frontiers in Pharmacology·Bushra ShalSalman Khan
Jul 4, 2019·Current Pharmaceutical Design·Ana PaunkovGerasimos P Sykiotis
Mar 10, 2016·Neurotoxicity Research·Silvia Lima CostaJuan Segura-Aguilar
Aug 2, 2016·British Journal of Pharmacology·G J McBeanF K Wallner
Dec 10, 2019·Oxidative Medicine and Cellular Longevity·Solomon Habtemariam

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.