Naringenin protects against oxido-inflammatory aberrations and altered tryptophan metabolism in olfactory bulbectomized-mice model of depression

Toxicology and Applied Pharmacology
Yashika BansalAnurag Kuhad

Abstract

Oxido-inflammatory aberrations play a substantial role in the pathophysiology of depression. Oxido-inflammatory stress increases catabolism of tryptophan into kynurenine which leads to imbalance in kynurenine and serotonin levels in the brain. Naringenin a flavonoid, has been reported to possess antidepressant property by restoring serotonin and noradrenaline levels in the brain. Its effects on oxido-inflammatory aberrations in depression has not been investigated. With this background, the present study was designed to investigate the antidepressant-like potential of naringenin in olfactory bulbectomy (OBX)-induced neuroinflammation, oxidative stress, altered kynurenine pathway, and behavioural deficits in BALB/c mice. OBX-mice showed depression-like behavioural alterations characterized by hyperactivity in open field, increased immobility time in forced swim test and decreased sucrose preference. After 14 days, OBX-mice were treated by gavage with naringenin (25, 50 and 100 mg/kg) and fluoxetine (5 mg/kg) for two weeks. Naringenin significantly ameliorated depression-like behavioural alterations. Naringenin significantly restored corticosterone levels in serum and antioxidant enzymes (Catalase, SOD GSH), nitrite and MDA in ce...Continue Reading

Citations

Jul 18, 2019·Metabolic Brain Disease·Ravinder Naik DharavathKanwaljit Chopra
Jul 14, 2020·Artificial Cells, Nanomedicine, and Biotechnology·Tong LiuWeisheng Feng
May 23, 2020·Scientific Reports·Roberto Farina de AlmeidaDiogo O Souza
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Feb 19, 2021·Neurochemical Research·Shiyana AroraKanwaljit Chopra
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