Naringin Ameliorates Haloperidol-Induced Neurotoxicity and Orofacial Dyskinesia in a Rat Model of Human Tardive Dyskinesia.

Neurotoxicity Research
Mao-Hsien WangHung-Sheng Soung


Animal models of haloperidol (HAL)-induced neurotoxicity and orofacial dyskinesia (OD) have long been used to study human tardive dyskinesia (TD). Similar to patients with TD, these models show strong pathophysiological characteristics such as striatal oxidative stress and neural cytoarchitecture alteration. Naringin (NAR), a bioflavonoid commonly found in citrus fruits, has potent antioxidative, anti-inflammatory, antiapoptotic, and neuroprotective properties. The present study evaluated the potential protective effects of NAR against HAL-induced OD in rats and the neuroprotective mechanisms underlying these effects. HAL treatment (1 mg/kg i.p. for 21 successive days) induced OD development, characterized by increased vacuous chewing movement (VCM) and tongue protrusion (TP), which were recorded on the 7th, 14th, and 21st day of drug treatment. NAR (30, 100, and 300 mg/kg) was administered orally 60 min before HAL injection for 21 successive days. On the 21st day, after behavioral testing, the rats were sacrificed, and the nitrosative and oxidative status, antioxidation power, neurotransmitter levels, neuroinflammation, and apoptotic markers in the striatum were measured. HAL induced OD development, with significant increases ...Continue Reading


Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Mar 1, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Bhavik Anil PatelDanny O'Hare
Jun 15, 2005·Pharmacology, Biochemistry, and Behavior·Marilise E BurgerJoão B T Rocha
Aug 22, 2007·The American Journal of Chinese Medicine·Min WeiWing Cho Sse
Sep 21, 2007·Nature Reviews. Neuroscience·Vittorio CalabreseAnna Maria Giuffrida Stella
Jul 2, 2008·European Journal of Pharmacology·Mahendra BishnoiShrinivas K Kulkarni
Jan 11, 2012·Methods in Molecular Biology·Mahendra Bishnoi, Ravneet K Boparai
Mar 14, 2012·Diabetes Research and Clinical Practice·Hamendra Singh ParmarAnil Kumar
Nov 6, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chul-Hyun Cho, Heon-Jeong Lee
Mar 13, 2013·International Journal of Molecular Sciences·Dong-Mei WangLian-Feng Zhang
Oct 29, 2013·Mini Reviews in Medicinal Chemistry·Martina RaudenskaMichal Masarik
Apr 9, 2014·Planta medica·Saurabh BhartiDharamvir Singh Arya
Dec 3, 2014·Pharmacology, Biochemistry, and Behavior·Anand Kamal SachdevaKanwaljit Chopra
Aug 27, 2016·Pharmaceutical Biology·Rui ChenQi-Yan Li
Nov 12, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Arumugam RamakrishnanMani Renuka
Jun 24, 2017·Nutritional Neuroscience·Dinesh DhingraNidhi Gahalain
Aug 16, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Gollapalle Lakshminarayanashastry ViswanathaYogananda Moolemath
Oct 13, 2017·The Journal of Clinical Psychiatry·Christoph U CorrellLeslie L Citrome
Jan 30, 2018·The Chinese Journal of Physiology·Cheng-Neng ChenHung-Sheng Soung
Apr 10, 2018·Neurotoxicity Research·Hung-Sheng SoungHsiang-Chien Tseng
Aug 22, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jian CuiSubhash L Bodhankar
Nov 7, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Benneth Ben-AzuEzekiel O Iwalewa
Feb 15, 2019·Frontiers in Pharmacology·Xuan ZengHongliang Yao
Jun 20, 2019·Current Protocols in Neuroscience·Fausto Pierdoná GuzenDayane Pessoa de Araújo
Jun 30, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Salman AhmedSherif T S Hassan

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