Naringin attenuates enhanced cough, airway hyperresponsiveness and airway inflammation in a guinea pig model of chronic bronchitis induced by cigarette smoke

International Immunopharmacology
Yu-long LuoWei-Wei Su

Abstract

Naringin is a flavanone with various bioactivities including expectorant effect, antitussive effect and inhibitory effects on asthma and acute lung injury. In present study we examined the effects of naringin on enhanced cough, airway hyperresponsiveness (AHR) and airway inflammation in chronic cigarette smoke (CS) exposure-induced chronic bronchitis in guinea pigs. To achieve this, guinea pigs were exposed to CS for 8weeks (10cigarettes/day, 6days/week). Oral administration of naringin (9.2, 18.4 and 36.8mg/kg) significantly attenuated the enhanced cough and AHR in smoke-exposed guinea pigs, reduced the concentrations of interleukin-8 (IL-8), leukotriene B4 (LTB4) and tumor necrosis factor-α (TNF-α) in bronchoalveolar lavage fluid (BALF) and decreased the myeloperoxidase (MPO) activity in both BALF and lung tissue, but did not significantly decrease the leukocytes in BALF. Naringin also improved superoxidase dismutase (SOD) activity in lung tissue and increased the content of lipoxin A4 (LXA4) in BALF in this guinea pig model of chronic bronchitis. These results suggested that naringin exhibited antitussive, anti-AHR and anti-inflammation effects on chronic CS exposure-induced chronic bronchitis in guinea pigs, and may possess...Continue Reading

References

Jan 1, 1994·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·M FujimuraT Matsuda
Sep 1, 1993·Environmental Health Perspectives·C A Pope, X Xu
Jun 1, 1993·Free Radical Biology & Medicine·H A LehrK Messmer
Mar 1, 1997·Chest·C E McEvoy, D E Niewoehner
Jun 3, 1999·American Journal of Respiratory and Critical Care Medicine·S A ComhairS C Erzurum
Jun 19, 2001·The European Respiratory Journal·A M ScholsE F Wouters
Jan 30, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Seon Min JeonMyung Sook Choi
Jun 21, 2002·Biochemical and Biophysical Research Communications·Kimiko AokiHitoshi Sato
Oct 24, 2002·The European Respiratory Journal. Supplement·K F Chung
Oct 11, 2005·Respiratory Medicine·Suleyman S HacievliyagilIsmail Temel
Dec 22, 2005·Nature Immunology·Charles N Serhan, John Savill
Apr 28, 2006·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Morton Lomask
Feb 3, 2007·The Journal of Allergy and Clinical Immunology·Jennifer Kathleen Quint, Jadwiga Anna Wedzicha
Jun 2, 2007·The European Respiratory Journal·A H MoriceUNKNOWN European Respiratory Society (ERS)
Aug 1, 2007·Pulmonary Pharmacology & Therapeutics·Bao-qin LinHui Ji
Sep 4, 2007·Lancet·David M Mannino, A Sonia Buist
Jan 29, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Andrew ChurgJoanne L Wright
May 6, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Joanne L WrightAndrew Churg
Sep 30, 2009·British Journal of Pharmacology·Paola Maderna, Catherine Godson
Oct 20, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Satomi OnoueShizuo Yamada

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Citations

Oct 3, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Yu-long LuoWei-wei Su
Jul 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Peibo LiKejian Zhang
Jun 18, 2014·European Journal of Drug Metabolism and Pharmacokinetics·Wei ZouKejian Zhang
Jan 28, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Peibo LiWeiwei Su
Jul 15, 2015·Pulmonary Pharmacology & Therapeutics·Hao-yan JiaoLi-li He
Jun 27, 2006·Pulmonary Pharmacology & Therapeutics·Néstor A Molfino, Peter K Jeffery
Aug 27, 2016·Pharmaceutical Biology·Rui ChenQi-Yan Li
Apr 13, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xuan ZengHongliang Yao
Jun 1, 2018·Drug Development and Industrial Pharmacy·Jingjing WangYourui Xu
Feb 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Minyi GuanWeiwei Su
Jul 2, 2019·Journal of Medicinal Food·Rui ShiWei-Wei Su
Feb 11, 2020·Frontiers in Veterinary Science·Brisa M Hsieh, Alicia K Beets
Nov 7, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Benneth Ben-AzuEzekiel O Iwalewa
Feb 19, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Kai NiLinhong Deng

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