Naringin attenuates liver damage in streptozotocin-induced diabetic rats

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Valeria RodríguezN Tolosa de Talamoni

Abstract

The aim of this study was to evaluate whether NAR has a hepatoprotective role in a model of STZ-induced diabetes and to elucidate the underlying mechanisms triggered by the flavonoid. Male Wistar rats were divided into three groups: 1) controls, 2) STZ rats 3) STZ rats treated daily with NAR (40 mg/kg b.w.) for 30 days. NAR prevented increases in serum aminotransferases and alkaline phosphatase activities in STZ rats. The flavonoid blocked serum lipid alterations, but not the biometric parameters in STZ rats. Microscopic examination in liver from STZ rats revealed morphological changes indicative of increased adipogenesis and cell death and inflammation, which were all mitigated by the flavonoid. NAR inhibited the NFκB/IL-6/Cox-2 overexpressions triggered by oxidative stress in STZ rats. The iNOS/NO/nitrosylated protein pathway was also blocked by NAR. The increment in the protein expression of Fas/FasL/caspase-3 and in the Bax/Bcl-2 ratio showed that both pathways of apoptosis were increased by the diabetes, effects that were abrogated by NAR treatment. In conclusion, NAR protects against the liver damage caused by STZ-induced diabetes and it could be a novel therapeutic strategy to prevent the non alcoholic fatty liver diseas...Continue Reading

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Citations

Nov 22, 2018·Journal of Radiation Research·Xiaoyan Chen, Chunjuan Fang
Feb 19, 2020·Phytotherapy Research : PTR·Kobra ShiraniGholamreza Karimi
Jun 13, 2020·Journal of Physiology and Biochemistry·Heba A Abdel-HamidNisreen D M Toni
Jun 24, 2020·Cancer Chemotherapy and Pharmacology·Romina KohanGabriela Picotto
Nov 16, 2019·International Journal of Biological Macromolecules·Ganesan ArunSingaram Kandasamy
Jan 6, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Beihui HeZhiyun Chen
Dec 22, 2020·Therapeutic Advances in Musculoskeletal Disease·Kristin E YuFrancis Y Lee
Feb 9, 2021·Journal of Diabetes and Metabolic Disorders·Pouya SalahiMasoud Alirezaei
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Guang-Jiang ShiYong Yang
Aug 17, 2021·Food Science and Biotechnology·Tae Wook KimUy Dong Sohn
Apr 12, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rujuan XinQuangang Zhu
Nov 19, 2021·Critical Reviews in Food Science and Nutrition·Yao ChenZhiyong He

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