Naringin does not alter caffeine pharmacokinetics, energy expenditure, or cardiovascular haemodynamics in humans following caffeine consumption

Clinical and Experimental Pharmacology & Physiology
Tasha L P BallardMatthew D Vukovich

Abstract

1. Naringin, a grapefruit constituent interacts with many medications including caffeine, a popular weight loss supplement. The purpose of the current study was to identify changes in caffeine pharmacokinetics, resting energy expenditure (REE), oxygen consumption (VO(2)) and respiratory exchange ratio (RER) after an acute dosage of caffeine and naringin. 2. Using a double-blinded, counterbalanced design, REE, VO(2), and RER were measured before and systematically for 8 h after a single dosage of caffeine (CAF, 200 mg) with and without naringin (100 mg (CN100) or 200 mg (CN200)) in 10 apparently healthy individuals. A standardized meal was provided following 240-minute measurements (400 kcals; 35 g carbohydrate; 27 g protein; 7 g fat). 3. Caffeine, CN100, CN200 did not alter VO(2) or VO(2) area under the curve (137 301 +/- 8318, 139 729 +/- 9300, 134 297 +/- 8318, mL/480 min). Resting energy expenditure (k/cals) was 10.0 +/- 1.4% higher with CAF versus CN200 (6.0 +/- 1.4%) and CN100 (6 +/- 1.5%) at 240 min (P = 0.07) which was then negated following a standardized meal. Percent change in RER from pre to 240 min and pre to 480 min was not different between the CAF, CN100, or CN200 (-0.2 +/- 1.7%, 1.7 +/- 1.7%, -2.8 +/- 1.9%). 4. ...Continue Reading

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Citations

Jul 12, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Constantin DallasFrançois-Xavier Bernard
Sep 26, 2015·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Jinqing HuYuguan Wen
Dec 15, 2010·Drugs·Kay SedenDavid Back
Jul 2, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Justyna BrzezichaMałgorzata Grembecka

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