Naringin protects against anoxia/reoxygenation-induced apoptosis in H9c2 cells via the Nrf2 signaling pathway

Food & Function
R C ChenX B Sun

Abstract

Naringin (Nar) is a major and active flavanone glycoside derivative of several citrus species. The antioxidant properties of Nar have an important function in its cardioprotective effects in various models. However, the effects of Nar on Nrf2 activation and the expression of its downstream genes in myocardial cells are yet to be elucidated. This study was designed to investigate the protective effects of Nar against anoxia/reoxygenation (A/R)-induced injury in H9c2 cells and determine its effects on the activity of Nrf2 and the expression of phase II antioxidant enzymes. H9c2 cells were pretreated with Nar for 6 h before exposure to A/R. A/R treatment severely injured the H9c2 cells, which was accompanied by apoptosis. Nar also suppressed the A/R-induced mitochondrial membrane depolarization and caspase-3 activation. Nar pretreatment significantly reduced the apoptotic rate by enhancing the endogenous anti-oxidative activity of superoxide dismutase, glutathione peroxidase, and catalase, thereby inhibiting intracellular reactive oxygen species generation. Moreover, the presence of Nar alone in H9c2 cells increased the nuclear translocation of Nrf2 in a dose- and time-dependent manner, as well as consistently increased the protei...Continue Reading

References

Feb 28, 1994·Biochemical and Biophysical Research Communications·M GschwendtF Marks
Jan 20, 2000·Journal of the National Cancer Institute·L Le MarchandL N Kolonel
Mar 27, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Laurie M Zipper, R Timothy Mulcahy
Apr 24, 2003·Experimental Biology and Medicine·Yen-Hsu ChenMark A Perrella
Sep 24, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Seon-Min JeonMyung-Sook Choi
Jul 13, 2005·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·L Maximilian Buja
Dec 16, 2005·Molecular and Cellular Biology·Akira KobayashiMasayuki Yamamoto
Aug 2, 2006·EMBO Reports·Satoko Nishimoto, Eisuke Nishida
Feb 1, 2007·Redox Report : Communications in Free Radical Research·Richard C M SiowGiovanni E Mann
Aug 19, 2007·Trends in Pharmacological Sciences·Stephen P Soltoff
Apr 9, 2008·Physiological Reviews·Elizabeth Murphy, Charles Steenbergen
Feb 3, 2009·The Journal of Biological Chemistry·Truyen NguyenCecil B Pickett
May 22, 2009·Journal of Agricultural and Food Chemistry·Cristina AngeloniSilvana Hrelia
Jan 12, 2010·The Journal of Biological Chemistry·Simon FourquetMichel B Toledano
Feb 18, 2011·Journal of Cellular Biochemistry·Jessica Cassavaugh, Karen M Lounsbury
Nov 9, 2011·Nature Medicine·Holger K Eltzschig, Tobias Eckle
Feb 9, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kwang Suk LimYong-Hee Kim
Feb 15, 2013·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yi MiaoWeijin Zang
Oct 15, 2013·Basic & Clinical Pharmacology & Toxicology·Jingfu ChenKeng Wu
Feb 15, 2014·Journal of Physiology and Biochemistry·Tharmarajan RamprasathGovindan Sadasivam Selvam
Jul 12, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Young-Sam Keum, Bu Young Choi
Sep 13, 2014·Oxidative Medicine and Cellular Longevity·Jichun HanQiusheng Zheng

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Citations

Mar 30, 2016·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Renata M MartinezRubia Casagrande
May 19, 2016·Journal of Natural Products·Andressa T FujimuraRubia Casagrande
Jun 4, 2016·Journal of Neurosurgery·Abuzer GüngörAlbert L Rhoton
Oct 8, 2016·Environmental Toxicology and Pharmacology·Liu XianchuDing Yang
Nov 2, 2016·Analytical Chemistry·Hana Vaisocherová-LísalováJiří Homola
Oct 23, 2016·Fish & Shellfish Immunology·Junhui ShaoJunfa Yuan
Apr 20, 2017·Journal of Biochemical and Molecular Toxicology·Visesh Kumar RathiBola Sadashiva Satish Rao
May 23, 2017·Nutrients·Rosanna MatteraRoberto Bei
May 2, 2018·World Journal of Gastroenterology : WJG·Erika Hernández-Aquino, Pablo Muriel
May 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guangxiang LuanHonglun Wang
Sep 11, 2020·European Journal of Pharmacology·Reza Heidary MoghaddamMohammad Hosein Farzaei
May 17, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Adio J AkamoOluwatosin E Cole

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