Narp regulates long-term aversive effects of morphine withdrawal.

Behavioral Neuroscience
Irving M RetiJay M Baraban

Abstract

Although long-lasting effects of drug withdrawal are thought to play a key role in motivating continued drug use, the mechanisms mediating this type of drug-induced plasticity are unclear. Because Narp is an immediate early gene product that is secreted at synaptic sites and binds to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, it has been implicated in mediating enduring forms of synaptic plasticity. In previous studies, the authors found that Narp is selectively induced by morphine withdrawal in the extended amygdala, a group of limbic nuclei that mediate aversive behavioral responses. Accordingly, in this study, the authors evaluate whether long-term aversive effects of morphine withdrawal are altered in Narp knockout (KO) mice. The authors found that acute physical signs of morphine withdrawal are unaffected by Narp deletion. However, Narp KO mice acquire and sustain more aversive responses to the environment conditioned with morphine withdrawal than do wild type (WT) controls. Paradoxically, Narp KO mice undergo accelerated extinction of this heightened aversive response. Taken together, these studies suggest that Narp modulates both acquisition and extinction of aversive responses to morphine...Continue Reading

References

Mar 11, 1977·Science·C P O'BrienB Wells
Nov 26, 1993·Neuroscience Letters·M A MorganJ E LeDoux
Jul 23, 1999·Annals of the New York Academy of Sciences·G F Koob
Jul 13, 2000·Nature·G SchulteisB J Everitt
Aug 31, 2001·Nature Neuroscience·D M HutchesonA Dickinson
Sep 22, 2001·Pharmacology, Biochemistry, and Behavior·B KestA Juni
Oct 2, 2002·Journal of Neurochemistry·Irving M RetiJay M Baraban
Oct 3, 2002·Journal of Neurochemistry·Irving M RetiJay M Baraban
Nov 8, 2002·Nature·Mohammed R Milad, Gregory J Quirk
Nov 28, 2002·The European Journal of Neuroscience·Irving M RetiJay M Baraban
Jun 5, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Irving M Reti, Jay M Baraban
Oct 7, 2004·Learning & Memory·Francisco Sotres-BayonJoseph E LeDoux
Feb 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·François FrenoisCatherine Le Moine
Oct 28, 2005·Nature Neuroscience·George F Koob, Michel Le Moal
Jan 18, 2006·Biological Psychiatry·Francisco Sotres-BayonJoseph E LeDoux
Jun 2, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paul J KennyGeorge F Koob
Jun 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lisa BjartmarMark S Perin
Dec 8, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kim G C HellemansJonathan L C Lee
Jan 5, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ko ZushidaMasayuki Sekiguchi
May 10, 2007·Nature Protocols·Christopher L CunninghamPeter A Groblewski
Dec 7, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander W JohnsonIrving M Reti

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Citations

Jul 16, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karyn M MyersMichael Davis
Jan 1, 2011·ILAR Journal·Irving M RetiJay M Baraban
Apr 20, 2012·Drug and Alcohol Dependence·Teresa R FranklinAnna Rose Childress
Dec 17, 2009·Hormones and Behavior·Karla S FrohmaderLique M Coolen
Oct 2, 2009·Peptides·Richard J Bodnar
Jan 30, 2010·Neuroscience and Biobehavioral Reviews·Karyn M Myers, William A Carlezon
Oct 21, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrew D ChangIrving M Reti

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