Abstract
Duodenal biopsies are commonly obtained during esophagogastroduodenoscopy (EGD) but are very often histopathologically normal. Therefore, a more strategic method for evaluating the duodenal mucosa and avoiding unnecessary biopsies is needed. To examine the clinical utility of narrow band imaging (NBI) for evaluating duodenal villous morphology. We performed a prospective cohort study of adult patients at Mayo Clinic Rochester from 2013-2014 who were referred for EGD with duodenal biopsies. A staff endoscopist scored, in real-time, the NBI-based appearance of duodenal villi into one of three categories (normal, partial villous atrophy, or complete villous atrophy), captured ≥ 2 representative duodenal NBI images, and obtained mucosal biopsies therein. Images were then scored by an advanced endoscopist and gastroenterology fellow, and biopsies (gold standard) by a pathologist, in a masked fashion using the same three-category classification. Performing endoscopist, advanced endoscopist, and fellow NBI scores were compared to histopathology to calculate performance characteristics [sensitivity, specificity, positive and negative, negative predictive value (NPV), and accuracy]. Inter-rater agreement was assessed with Cohen's kappa....Continue Reading
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Citations
Oct 12, 2019·Immunological Medicine·Hiroto HiragaShinsaku Fukuda
Jul 23, 2020·Revista da Associação Médica Brasileira·Seval AkayHarun Akar
Jul 7, 2021·Gastrointestinal Endoscopy·Shraddha GulatiBu'Hussain Hayee