Narrow band ultraviolet B for the treatment of generalized lichen planus

Cutaneous and Ocular Toxicology
Berna SolakTeoman Erdem

Abstract

Although various treatment options have been used in the treatment of lichen planus (LP), it is still challenging to choose the most effective one. Scarce data are available in the literature examining efficacy of NB-UV in the treatment of LP. Thus, we aimed to evaluate efficacy of NB-UVB for LP. Twenty-four patients with generalized LP who received NB-UVB treatments in between January 2011 and December 2014 were included in the study. Response types were classified into three groups which complete response refers to ≥90% reduction in the number of the lesions; partial response 51-89%; and no response ≤50%. Sixteen patients responded to the NB-UVB treatment [5 partial (20.8%) and 11 complete (45.8%) remissions], whereas 8 patients (33.3%) did not respond to the treatment. A number of sessions and accordingly cumulative dose of UVB were significantly higher in responded group than in non-responders. When we compared these two groups according to duration of the disease, there was no significant difference. Two-thirds of patients with generalized LP favorably responded to NB-UVB treatment without any remarkable adverse events. This significant response rate coupled with safety should prompt further clarification of the place of N...Continue Reading

References

May 1, 1995·The Journal of Investigative Dermatology·T Yamamoto, T Osaki
Jan 6, 1999·Archives of Dermatology·B CribierO Chosidow
Aug 9, 2001·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·P MiddelH J Radzun
Jul 9, 2002·International Journal of Dermatology·Atul Taneja, Charles R Taylor
Aug 20, 2003·Photodermatology, Photoimmunology & Photomedicine·Sharam Samson YasharHenry W Lim
Oct 11, 2003·Photodermatology, Photoimmunology & Photomedicine·Hayriye SaricaoğluSükran Tunali
Mar 5, 2005·Annales de dermatologie et de vénéréologie·F HabibL Meunier
Mar 29, 2005·Journal of the American Academy of Dermatology·Thilo GambichlerAlexander Kreuter
May 13, 2005·Archives of Dermatological Research·Hekla SigmundsdottirHelgi Valdimarsson
Jan 27, 2007·Photodermatology, Photoimmunology & Photomedicine·Alexandra WackernagelPeter Wolf
Mar 21, 2008·Photodermatology, Photoimmunology & Photomedicine·Felix PavlotskyHenri Trau
Sep 6, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·H GamilF Ahmed
Jun 12, 2014·The Journal of Dermatological Treatment·Nasim Fazel

❮ Previous
Next ❯

Citations

Jul 3, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·H Husein-ElAhmedM Steinhoff
Jun 13, 2020·Journal of Cosmetic Dermatology·Fathia M Khattab, Mai A Samir
Jul 18, 2018·Frontiers in Medicine·Sally H Ibbotson
Mar 17, 2021·Acta Physiologica·Cameron R Moattari, Richard D Granstein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.