Narrow-band ultraviolet B radiation induces the expression of β-endorphin in human skin in vivo

Journal of Photochemistry and Photobiology. B, Biology
Anna JussilaE Snellman

Abstract

Ultraviolet radiation (UVR) from the sun and solaria has addictive properties that may develop into dependence. In mice, UVR addiction was connected to β-endorphin (β-END) formed in the skin after UVR exposure. In humans, the formation of β-END in skin keratinocytes has not been confirmed in vivo. To determine with immunohistochemistry if sub-erythematous narrow-band UV-B (NB-UV-B) exposures stimulate p53 mediated expression of pro-opiomelanocortin (POMC), β-END and α-melanocyte stimulating hormone (α-MSH) in human skin keratinocytes in vivo. Within 12 healthy volunteers, 7 received a single 1 standard erythema dose (SED) of NB-UV-B on their whole body, and 5 volunteers received a cumulative dose of 3 SED delivered on two subsequent days i.e., 1+2 SED. Skin biopsies were taken immediately before the first exposure and at 24h from the last UV-B exposure to assess p53, β-END, POMC, and α-MSH expression. Nuclear p53 expression increased in all samples taken at 24h after NB-UV-B exposure. UV-B irradiation also increased epidermal β-END expression in 11 out of 12 samples taken at 24h after UV-B exposure. The brownish staining was localized in the cytoplasm of keratinocytes and around the nuclei, being more pronounced in the basal ce...Continue Reading

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Citations

Jun 12, 2019·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Darren MaysKenneth P Tercyak
Sep 14, 2020·The Journal of Investigative Dermatology·Marianna SannaMario Falchi
Mar 17, 2021·Acta Physiologica·Cameron R Moattari, Richard D Granstein
Oct 17, 2020·Critical Reviews in Toxicology·Juliana P PaivaMarcelo de Pádula
Nov 24, 2021·Journal of Cardiovascular Translational Research·Xin-Yun LiYuan-Yuan Sun

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