Narrowband ultraviolet B radiation suppresses contact hypersensitivity

Photodermatology, Photoimmunology & Photomedicine
Yoichi ShintaniAkimichi Morita

Abstract

A main mechanism responsible for the efficacy of narrowband ultraviolet (UV)B is thought to be the induction of apoptosis in pathogenetically relevant cells. Narrowband UVB therapy, however, generally induces a relatively long remission period. Recently, evidence that UVB radiation induces regulatory T (Treg) cells was reported. Based on these findings, we examined whether narrowband UVB suppresses contact hypersensitivity (CHS) by inducing Treg cells. The shaved abdomens of C3H/HeN mice were irradiated with broadband or narrowband UVB. CHS was defined as an ear-swelling response. To examine whether tolerance can be induced by adoptive transfer, lymph node cells from UVB-irradiated mice were injected into naïve mice before sensitization and CHS challenge. Narrowband UVB exposure dose dependently suppressed CHS. Significant suppression was observed at doses between 1000 and 3000 mJ/cm(2) (P<0.05). The suppressive effect achieved with 1000 mJ/cm(2) narrowband UVB was very similar to the effect achieved with 100 mJ/cm(2) broadband UVB. The suppressive effects on CHS were transferred to naïve mice by the injection of lymph node cells from tolerant mice. Narrowband UVB induced local and systemic suppression of CHS. In addition, narr...Continue Reading

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Citations

Aug 15, 2012·Photomedicine and Laser Surgery·Nicola ZerbinatiTommaso Iannitti
Nov 6, 2012·Progress in Lipid Research·Alexandra C Kendall, Anna Nicolaou
Apr 5, 2011·Journal of Dermatological Science·Atsuko KamoKenji Takamori
Dec 17, 2008·Journal of Dermatological Science·Chiyo SaitoAkimichi Morita
Dec 16, 2011·The Journal of Investigative Dermatology·Jean KrutmannJin Ho Chung
Jan 21, 2009·Photodermatology, Photoimmunology & Photomedicine·Keiko KobayashiAkimichi Morita
Sep 29, 2011·Photodermatology, Photoimmunology & Photomedicine·Emi NishidaAkimichi Morita
Jan 1, 2014·Photodermatology, Photoimmunology & Photomedicine·Nayera H MoftahNancy A M Ali
Nov 22, 2016·Scientific Reports·Cheng-Che E LanGwo-Shing Chen
Jan 26, 2018·The Journal of Dermatology·Akimichi Morita
Jun 28, 2013·Experimental Dermatology·Motoki NakamuraAkimichi Morita
Nov 12, 2019·Frontiers in Microbiology·Else S BosmanBruce A Vallance

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