PMID: 9420535Jan 8, 1998Paper

Narrowband UV-B produces superior clinical and histopathological resolution of moderate-to-severe psoriasis in patients compared with broadband UV-B

Archives of Dermatology
T R CovenJames G Krueger

Abstract

To compare the therapeutic effectiveness of daily exposure to narrowband (NB) UV-B vs broadband (BB) UV-B with and without tar. Half-body exposures to NB UV-B or BB UV-B were given daily for 4 weeks in this comparative treatment study. Narrowband UV-B was delivered from TL-01 fluorescent bulbs and BB UV-B from conventional bulbs in the same phototherapy cabinet. Narrowband UV-B was compared using a paired treatment approach to BB UV-B above the waist and to BB UV-B with tar (Goeckerman treatment) below the waist. General clinical research center of a university hospital inpatient unit. Twenty-two patients with moderate-to-severe plaque-type psoriasis completed the study. Clinical efficacy was measured weekly using psoriasis severity scoring. Therapeutic outcomes after 4 weeks were compared in paired biopsy samples from treated lesions using objective histopathological measures (quantitative reduction in epidermal acanthosis and keratin 16 expression). Clinical resolution of psoriasis was achieved on 86% of paired sites treated with NB UV-B vs 73% treated with BB UV-B. Histopathological resolution of epidermal hyperplasia (marked by keratin 16 expression) was achieved in 88% of lesions treated with NB UV-B vs 59% treated with BB...Continue Reading

Citations

May 15, 2007·Archives of Dermatological Research·A NastB Rzany
Feb 22, 2012·Archives of Dermatological Research·A NastUNKNOWN Berufsverband Deutscher Dermatologen
Dec 4, 2012·Dermatology and Therapy·Bruce E StroberMelodie Young
Jul 21, 2004·Clinics in Dermatology·Elizabeth Knobler
Feb 28, 2004·Journal of the American Academy of Dermatology·Mark LebwohlSteven R Feldman
Apr 11, 2003·Lancet·Mark Lebwohl
Mar 31, 1999·Journal of Dermatological Science·K Danno
May 15, 2002·Journal of Photochemistry and Photobiology. B, Biology·Zoltán NovákLajos Kemény
Mar 26, 2002·The Pharmacogenomics Journal·J L OestreicherW L Trepicchio
Jun 26, 2001·The British Journal of Dermatology·R G GoodwinA V Anstey
Apr 13, 2005·Acta Dermato-venereologica·Mark BerneburgFrauke Benedix
Feb 17, 1999·The Journal of Experimental Medicine·M OzawaJ G Krueger
Oct 13, 2007·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Thomas BrockowRalf Uwe Peter
Jul 17, 2008·Photochemistry and Photobiology·Peter L LeePiet L B Bruijnzeel
Feb 15, 2005·Annals of the Rheumatic Diseases·M LebwohlJ Y M Koo
Aug 12, 2006·Dermatology : International Journal for Clinical and Investigative Dermatology·Simone Maria GoldingerSeverin Lauchli
Dec 10, 1999·The Journal of Clinical Investigation·W L TrepicchioJ G Krueger
Nov 17, 2010·Indian Journal of Dermatology, Venereology and Leprology·Sunil Dogra, Dipankar De
Dec 17, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jaap De LeeuwH A Martino Neumann
Nov 22, 2014·Dermatologic Clinics·Emoke Racz, Errol P Prens
Sep 6, 2001·Clinics in Geriatric Medicine·A van VoorheesV P Werth
Jun 13, 2006·The Journal of Dermatological Treatment·Sarah G Hodulik, Joshua A Zeichner
Sep 14, 2007·The Journal of Dermatological Treatment·Gregory L SimpsonSteven R Feldman
Jul 13, 2002·Expert Review of Anticancer Therapy·N Apisarnthanarax, M Duvic
May 16, 2007·The Journal of Investigative Dermatology. Symposium Proceedings·Jennifer K TanAlice B Gottlieb
Dec 12, 2013·The Journal of Investigative Dermatology. Symposium Proceedings·Amy J McMichael
Nov 30, 2011·Seminars in Cutaneous Medicine and Surgery·Zain U Syed, Iltefat H Hamzavi
Jul 19, 2011·The Journal of Allergy and Clinical Immunology·Suzanne TintleEmma Guttman-Yassky
Mar 25, 2011·Journal of the American Academy of Dermatology·Whitney LapollaSteven R Feldman
Jun 29, 2010·Seminars in Cutaneous Medicine and Surgery·Rupa Pugashetti, John Koo
Feb 3, 2009·Journal of the American Academy of Dermatology·Kapila V Paghdal, Robert A Schwartz
Aug 10, 2007·The Journal of Investigative Dermatology·Makoto KunisadaChikako Nishigori
Sep 2, 2011·The Journal of Investigative Dermatology·Milène Kennedy-CrispinJames G Krueger
Nov 16, 2012·The Journal of Investigative Dermatology·Milène Kennedy CrispinJames G Krueger
Mar 24, 2007·The Journal of Investigative Dermatology·Sandra M KirkePeter M Farr
May 27, 2011·The Journal of Investigative Dermatology·Sophie C WeatherheadNick J Reynolds
Nov 17, 2007·The Journal of Investigative Dermatology·Marianna L BlyuminRobert S Kirsner
Aug 26, 2004·The British Journal of Dermatology·S H IbbotsonUNKNOWN British Association of Dermatologists
Sep 17, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·J P OrtonneJ Choi
Aug 12, 2004·International Journal of Dermatology·Grace D Bandow, John Y M Koo
Oct 20, 2005·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Mark BerneburgMartin Röcken

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.