Narrowing the diversification of supramolecular assemblies by preorganization

Chemical Communications : Chem Comm
Zhongyan WangZhimou Yang

Abstract

We designed and synthesized three phosphorylated peptides as precursors of the same peptide Nap-YYY. We found that different precursors led to different materials with almost identical chemical compositions at the final stages. Only Nap-YpYY could form very uniform nanofibers in a stable supramolecular hydrogel by enzyme-instructed self-assembly (EISA) at the physiological temperature (37 °C). In contrast, de-phosphorylation of the other two precursors (Nap-pYYY and Nap-YYpY) resulted in diverse nanostructures in metastable hydrogels with precipitates. The formation of uniform nanomaterials in the stable hydrogels was due to the preorganization property of the precursor Nap-YpYY, which facilitated rapid folding and accelerated the kinetics of hydrogelation of the resulting peptide Nap-YYY generated by the EISA process. Our study demonstrated the importance of the precursor for the self-assembly of nanomaterials and provided a useful strategy to manipulate them.

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Citations

Apr 25, 2019·Advanced Materials·Jie GaoZhimou Yang
Mar 16, 2021·Frontiers in Bioengineering and Biotechnology·Tianyue JiangRan Mo
Mar 24, 2021·Cell Proliferation·Wensi LiuJianping Li
Aug 20, 2020·Chemical Reviews·Hongjian HeBing Xu
May 1, 2020·ACS Applied Materials & Interfaces·Chunhui LiangJie Gao
Dec 21, 2019·The Journal of Organic Chemistry·Ferran EsteveSantiago V Luis

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Methods Mentioned

BETA
EISA
peptide folding
transmission microscopy
circular dichroism

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