Narrowing the Expertise Gap for Predicting Intracranial Aneurysm Hemodynamics: Impact of Solver Numerics versus Mesh and Time-Step Resolution.

AJNR. American Journal of Neuroradiology
M O KhanDavid A Steinman

Abstract

Recent high-resolution computational fluid dynamics studies have uncovered the presence of laminar flow instabilities and possible transitional or turbulent flow in some intracranial aneurysms. The purpose of this study was to elucidate requirements for computational fluid dynamics to detect these complex flows, and, in particular, to discriminate the impact of solver numerics versus mesh and time-step resolution. We focused on 3 MCA aneurysms, exemplifying highly unstable, mildly unstable, or stable flow phenotypes, respectively. For each, the number of mesh elements was varied by 320× and the number of time-steps by 25×. Computational fluid dynamics simulations were performed by using an optimized second-order, minimally dissipative solver, and a more typical first-order, stabilized solver. With the optimized solver and settings, qualitative differences in flow and wall shear stress patterns were negligible for models down to ∼800,000 tetrahedra and ∼5000 time-steps per cardiac cycle and could be solved within clinically acceptable timeframes. At the same model resolutions, however, the stabilized solver had poorer accuracy and completely suppressed flow instabilities for the 2 unstable flow cases. These findings were verifie...Continue Reading

References

Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P F DaviesM A Gimbrone
Nov 1, 1970·Journal of Neurosurgery·G G Ferguson
Feb 1, 1994·Stroke; a Journal of Cerebral Circulation·Y KurokawaK Watanabe
Nov 15, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Charles R WhiteJohn A Frangos
May 22, 2009·Biorheology·Luca Antiga, David A Steinman
Jan 21, 2010·Physiological Measurement·Yiemeng HoiDavid A Steinman
Apr 9, 2011·AJNR. American Journal of Neuroradiology·T SchubertS Wetzel
Apr 16, 2011·AJNR. American Journal of Neuroradiology·D F Kallmes
Sep 21, 2011·Nature Reviews. Neurology·Timo KringsFranz-Josef Hans
Jan 24, 2012·AJNR. American Journal of Neuroradiology·D F Kallmes
Oct 16, 2012·Journal of Biomechanics·Simona HodisDan Dragomir-Daescu
Nov 24, 2012·Journal of Biomechanics·Kristian Valen-SendstadDavid A Steinman
Dec 12, 2012·Annals of Biomedical Engineering·Jennifer M DolanHui Meng
Feb 8, 2014·AJNR. American Journal of Neuroradiology·Y Ventikos

❮ Previous
Next ❯

Citations

Dec 25, 2015·Annals of Biomedical Engineering·Michela BozzettoAndrea Remuzzi
Aug 10, 2015·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Krishna S NayakSubha V Raman
Oct 4, 2016·International Journal for Numerical Methods in Biomedical Engineering·M O KhanK Valen-Sendstad
Jun 8, 2017·Artificial Organs·David FulkerTracie Barber
Aug 19, 2016·Journal of Biomechanical Engineering·David FulkerTracie Barber
Apr 3, 2020·Journal of Cardiovascular Translational Research·Muhammad Owais KhanAlison L Marsden
Nov 28, 2019·Journal of Neurointerventional Surgery·Nicole M CancelliereDavid A Steinman
Mar 28, 2020·Annual Review of Biomedical Engineering·Vitaliy L Rayz, Aaron A Cohen-Gadol
Dec 11, 2019·International Journal for Numerical Methods in Biomedical Engineering·Amirhossein Arzani
Jul 7, 2020·International Journal for Numerical Methods in Biomedical Engineering·Isaac Perez-RayaRoshan M D'Souza
Jul 1, 2017·Cardiovascular Engineering and Technology·Bogdan Ene-Iordache, Andrea Remuzzi
Apr 3, 2019·Cardiovascular Engineering and Technology·Viviana ManciniKristian Valen-Sendstad
Sep 12, 2018·Cardiovascular Engineering and Technology·Kristian Valen-SendstadDavid A Steinman
Aug 23, 2020·Journal of Biomechanics·Thangam NatarajanDavid A Steinman
Jun 23, 2021·Computers in Biology and Medicine·Milad HabibiAmirhossein Arzani
Jun 19, 2021·Frontiers in Cardiovascular Medicine·Lauren JohnstonAsimina Kazakidi
Aug 28, 2021·International Journal for Numerical Methods in Biomedical Engineering·Dimitrios S LampropoulosVassilios C Loukopoulos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Related Papers

Journal of Biomechanical Engineering
Gordon R Stuhne, David A Steinman
Journal of the Royal Society, Interface
Christian PoelmaYiannis Ventikos
Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Alvaro ValenciaEduardo Bravo
© 2022 Meta ULC. All rights reserved