Nasal-bone length in euploid fetuses at 16-24 weeks' gestation by three-dimensional ultrasound

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
Nicola PersicoKypros H Nicolaides

Abstract

To establish a normal range of nasal-bone length at 16-24 weeks' gestation by the use of three-dimensional (3D) ultrasound and to investigate the effect of deviations from the exact mid-sagittal plane on the measurement of nasal-bone length. We acquired 3D volumes of the fetal profile from 135 normal fetuses at 16-24 weeks' gestation. The multiplanar mode was used to obtain the exact mid-sagittal plane and to produce parasagittal and oblique views of the fetal face. Nasal-bone length was measured in each plane and the sonographic landmarks of each profile view were examined. Nasal-bone length increased with gestational age from a mean of 4.1 mm at 16 weeks to 7.1 mm at 24 weeks. There was a tendency to underestimate nasal-bone length when the measurements were taken in parasagittal planes and to overestimate the measurements when they were taken in oblique views, compared to the exact mid-sagittal plane. The mean difference in nasal-bone length from the one in the mid-sagittal plane was 0.42 and 0.63 mm for parasagittal measurements at 1 and 2 mm, respectively, from the midline, -0.08 and -0.51 mm for oblique measurements at 10 degrees and 20 degrees rotation along the z-axis and -0.69 mm for rotation of 20 degrees along the z-...Continue Reading

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Citations

Aug 22, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·P PapasozomenouB C Tarlatzis
Aug 11, 2011·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·F I VosC M Bilardo
Jun 29, 2011·Prenatal Diagnosis·Filiz Fatma YanikBurcu Kisa Karakaya
May 18, 2011·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E A P De Jong-PleijC M Bilardo
Mar 1, 2016·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G CosselluK H Nicolaides
Dec 17, 2014·Journal of Perinatal Medicine·Panayiota PapasozomenouBasil C Tarlatzis
Oct 17, 2019·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Salih Burcin Kavak, Ebru Celik Kavak

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