Nasal cavity lining fluid ascorbic acid concentration increases in healthy human volunteers following short term exposure to diesel exhaust

Free Radical Research
A BlombergF J Kelly

Abstract

To determine if diesel exhaust (DE) exposure modifies the antioxidant defense network within the respiratory tract lining fluids, a randomized, single blinded, crossover control study using nasal lavage and flexible video bronchoscopy with bronchial and bronchoalveolar lavage was performed. Fifteen healthy, non-smoking, asymptomatic subjects were exposed to filtered air or diluted diesel exhaust (300mg m(-3) particulates, 1.6ppm nitrogen dioxide) for one hour on 2 separate occasions, at least three weeks apart. To examine the kinetics of any DE-induced antioxidant reactions, nasal lavage fluid and blood samples were collected prior to, immediately after, and 5 1/2 hours post exposure. Bronchoscopy was performed 6 hours after the end of DE exposure. Ascorbic acid, uric acid and reduced glutathione (GSH) concentrations were determined in nasal, bronchial, bronchoalveolar lavage and plasma samples. Malondialdehyde (MDA) and protein carbonyl concentrations were determined in plasma and bronchoalveolar lavage samples. Nasal lavage ascorbic acid concentration increased 10-fold during DE exposure [1.02 (0.26-2.09) Vs 7.13 (4.66-10.79) micromol/L(-1)], but returned to basal levels 5.5 hours post-exposure [0.75 (0.26-1.51) micromol/L(-1...Continue Reading

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Citations

Feb 4, 2003·Current Allergy and Asthma Reports·David Diaz-SanchezRiccardo Polosa
Feb 12, 2004·Archives of Biochemistry and Biophysics·Ian S MudwayFrank J Kelly
Dec 31, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ning LiAndre E Nel
Nov 5, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Theresa M BastainDavid Diaz-Sanchez
Jul 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ketan ShankardassKiros Berhane
Feb 11, 2004·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·L NikasinovicJ Just
Aug 18, 1999·Occupational and Environmental Medicine·B RudellT Sandström
Mar 18, 2000·Thorax·S O ShaheenP G Burney
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Jun 28, 2011·American Journal of Respiratory and Critical Care Medicine·Talat IslamRob McConnell
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S S SalviS Holgate
Sep 30, 2004·Free Radical Biology & Medicine·Bettina C SchockCarroll E Cross
Feb 10, 1999·The American Journal of Physiology·A van der VlietS Louie
Oct 12, 1999·The American Journal of Physiology·H ZielinskiF J Kelly

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